Transplantation between identical twins-

Isograft. ***Isograft*** - An **isograft** refers to a transplant between **genetically identical individuals**, such as identical twins, thus minimizing immune rejection [1]. - Due to the identical genetic makeup, the recipient's immune system will not recognize the transplanted tissue as foreign, making **immunosuppression unnecessary** [1]. *Xenograft* - A **xenograft** involves transplantation of tissues or organs between **different species**, for example, from a pig to a human. - These grafts typically face severe and rapid **immune rejection** due to significant genetic differences between the donor and recipient species. *Autograft* - An **autograft** is a transplant of tissue from **one part of an individual's body to another part of the same individual**. - This type of graft has no risk of rejection as the tissue is genetically identical to the recipient's own tissue [2]. *Allograft* - An **allograft** is a transplant between **genetically non-identical individuals of the same species**, such as between two non-twin humans. - These grafts always require **immunosuppressive therapy** to prevent rejection due to genetic differences, though rejection rates vary based on HLA matching [1].

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NEET-PG 2020 — Internal Medicine

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