NEET-PG 2019 Previous Year Questions Practice Questions

Q: Which of the following intravenous agents is known to cause pain upon injection?

Propofol. ***Propofol*** - **Propofol** is notoriously known to cause significant **pain upon injection**, especially when administered into smaller veins. - This is attributed to its **lipid emulsion formulation** and activation of **TRPA1 receptors** on sensory neurons. *Methohexital* - While **methohexital** can cause localized pain and venous irritation, it is generally less pronounced and less frequent than with propofol. - It is known more for causing **hiccups** and **muscle twitching** upon induction, rather than severe injection pain. *Ketamine* - **Ketamine** typically causes minimal to no pain upon intravenous injection. - Its side effects are often related to its **dissociative anesthetic** properties, such as psychomimetic effects and increased sympathetic activity. *Etomidate* - **Etomidate** is generally considered to be low in causing injection site pain. - Its primary concern is the potential for **adrenocortical suppression** and a high incidence of **myoclonus**. [Practice more NEET-PG 2019 questions on OnCourse]

Q: Which of the following is true about alpha-1 antitrypsin?

Inhibits elastase. ***Inhibits elastase*** - Alpha-1 antitrypsin (A1AT) primarily serves to **inhibit elastase**, a protease that can damage lung tissue, helping to protect the lungs from destruction [1]. - Deficiency of A1AT leads to **emphysema** and liver disease due to unchecked activity of elastase [1][2]. *Inhibits trypsin* - A1AT specifically does not primarily inhibit **trypsin**, which is involved in protein digestion in the intestine. - Although A1AT affects proteases, its main function is related to **elastase**, not trypsin [1]. *Inhibits trypsinogen activation in pancreas* - A1AT does not have a significant role in the **inhibition of trypsinogen activation** within the pancreas. - Instead, pancreatic enzyme regulation involves other mechanisms that do not involve A1AT's function. *Inhibits chymotrypsin* - A1AT is not known for inhibiting **chymotrypsin**, a serine protease derived from trypsinogen in the gut. - It specifically targets **elastase** and similar enzymes rather than chymotrypsin [1]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Liver and Gallbladder, pp. 856-858. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Lung, pp. 683-684. [Practice more NEET-PG 2019 questions on OnCourse]

Q: Which of the following is not the source of cytosolic NADPH ?

ATP citrate lyase. ***ATP citrate lyase*** - **ATP citrate lyase** is an enzyme involved in the synthesis of **acetyl-CoA** from citrate in the cytosol, which is then used for **fatty acid synthesis**. It does not generate NADPH. - While the **acetyl-CoA** produced is used in pathways that require NADPH, ATP citrate lyase itself does not directly produce NADPH. *Isocitrate dehydrogenase* - Cytosolic **isocitrate dehydrogenase** catalyzes the oxidative decarboxylation of **isocitrate** to alpha-ketoglutarate, producing **NADPH**. - This reaction is an important source of **cytosolic NADPH**, especially in non-photosynthetic tissues. *Malic enzyme* - **Malic enzyme** catalyzes the oxidative decarboxylation of **malate** to pyruvate, simultaneously reducing **NADP+ to NADPH**. - This enzyme is a significant source of **cytosolic NADPH** in various tissues, contributing to fatty acid synthesis and other reductive processes. *G6PD* - **Glucose-6-phosphate dehydrogenase (G6PD)** is the rate-limiting enzyme in the **pentose phosphate pathway** (PPP). - It catalyzes the first step of the PPP, converting **glucose-6-phosphate** to 6-phosphogluconolactone and producing **NADPH** as a crucial coenzyme. [Practice more NEET-PG 2019 questions on OnCourse]

Q: Esotropia is most commonly associated with:

Hyperopia. ***Hyperopia*** - **Hyperopia** (farsightedness) requires greater accommodative effort to focus on distant and near objects, which is coupled with **convergence**. This excessive convergence can lead to **esotropia** (inward turning of the eye). - Accommodative esotropia is a common type of strabismus directly linked to uncorrected hyperopia. *Presbyopia* - **Presbyopia** is an age-related loss of the eye's ability to focus on nearby objects due to stiffening of the lens, typically occurring after age 40. - It affects accommodation but does not primarily cause esotropia; rather, it makes near work difficult, and patients may prefer to hold objects further away to see them. *Astigmatism* - **Astigmatism** is a refractive error where the eye does not focus light evenly onto the retina due to an irregularly shaped cornea or lens, leading to blurred or distorted vision at all distances. - While it can cause visual discomfort and eye strain, it is not directly associated with the development of esotropia. *Myopia* - **Myopia** (nearsightedness) is a refractive error where distant objects appear blurry because light focuses in front of the retina. - High myopia can sometimes be associated with **exotropia** (outward turning of the eye) due to divergence excess, rather than esotropia. [Practice more NEET-PG 2019 questions on OnCourse]

Question 1

Which of the following intravenous agents is known to cause pain upon injection?

Accepted Answer

Propofol

Answer

Ketamine

Answer

Etomidate

Answer

Methohexital

Question 2

Which of the following is true about alpha-1 antitrypsin?

Accepted Answer

Inhibits elastase

Answer

Inhibits trypsin

Answer

Inhibits chymotrypsin

Answer

Inhibits trypsinogen activation

Question 3

Which of the following is not the source of cytosolic NADPH ?

Accepted Answer

ATP citrate lyase

Answer

Malic enzyme

Answer

G6PD

Answer

Isocitrate dehydrogenase

Question 4

Esotropia is most commonly associated with:

Accepted Answer

Hyperopia

Answer

Presbyopia

Answer

Astigmatism

Answer

Myopia

Question 5

What conditions can be diagnosed using the cover-uncover test?

Accepted Answer

Eye alignment disorders including strabismus and heterophoria

Answer

Convergent strabismus (Esotropia)

Answer

Latent misalignment (Heterophoria)

Answer

Strabismus (Squint)

Question 6

Esotropia is commonly seen in which type of refractive error?

Accepted Answer

Hypermetropia

Answer

Myopia

Answer

Astigmatism

Answer

Presbyopia

Question 7

Fish mouth stenosis in rheumatic heart disease is due to which of the following mechanisms?

Accepted Answer

Calcification and fibrosis bridging across valvular commissures

Answer

Fibrinoid necrosis

Answer

Acute inflammation leading to valvular damage

Answer

Myxomatous degeneration of the valve, which can occur in rheumatic heart disease

Question 8

Which of the following statements is true regarding a fixed-dose combination of drugs?

Accepted Answer

The adverse effect of one drug may be mitigated by the other drug.

Answer

The dose of one drug can be adjusted independently.

Answer

Adverse effects can be attributed solely to one drug.

Answer

Combining two drugs with different pharmacokinetics is straightforward.

Question 9

Carbapenem with the maximum seizure risk is:

Accepted Answer

Imipenem

Answer

Meropenem

Answer

Doripenem

Answer

Ertapenem

Question 10

Which of the following best demonstrates the variability in drug responsiveness among individuals?

Accepted Answer

Quantal Dose Response Curve

Answer

Potency

Answer

Efficacy

Answer

Graded Dose Response Curve

NEET-PG 2019

Anesthesiology

Biochemistry

Ophthalmology

Pathology

Pharmacology