NEET-PG 2018 Practice Questions

Q: Identify the function of the muscles marked in red:

Flexion at MCP joint. ***Flexion at MCP joint*** - The muscles shown in red are the **lumbricals**, which primarily function to **flex the metacarpophalangeal (MCP) joints** and **extend the interphalangeal (IP) joints**. - This is their most fundamental action when identifying lumbrical function, as they originate from **flexor digitorum profundus tendons** and insert into the **extensor expansion**, providing precise **MCP joint flexion**. - This unique action creates the **"lumbrical grip"** essential for precision handling. *Flexion at IP joint* - Lumbricals actually **extend the interphalangeal (IP) joints**, not flex them, making this option anatomically incorrect. - **Flexion at IP joints** is performed by the **flexor digitorum superficialis** (PIP joints) and **flexor digitorum profundus** (DIP joints). - The lumbrical insertion into the **extensor hood** produces IP extension, the opposite of this option. *Extension at MCP joint* - **Extension at the MCP joints** is primarily performed by the **extensor digitorum** and other **extrinsic extensor muscles**. - Lumbricals produce the opposite action, **flexing the MCP joints** rather than extending them. *Abduction at MCP joint* - **Abduction at the MCP joints** is primarily performed by the **dorsal interossei muscles** using the **DAB** (Dorsal ABduct) mnemonic. - Lumbricals do not contribute to **finger abduction** but rather focus on **MCP flexion, IP extension**, and **fine motor control**.

Q: Which is correct about structures marked as "X" found in smooth muscle?

Dense bodies. ***Dense bodies*** - The structures marked "X" are **dense bodies**, which are analogous to **Z-discs** in skeletal muscle, serving as attachment points for **actin filaments**. - They are crucial for transmitting the contractile force generated by the **actin-myosin bundles** to the cell membrane, leading to the characteristic corkscrew-like contraction of smooth muscle cells. *A band* - The **A band** is a region found in **striated muscle** (skeletal and cardiac muscle) where thick and thin filaments overlap, corresponding to the length of the myosin filaments. - Smooth muscle lacks the organized sarcomeric structure, and thus, **A bands** are not present. *Calmodulin* - **Calmodulin** is a calcium-binding protein that plays a key role in smooth muscle contraction by activating **myosin light chain kinase (MLCK)**. - However, it is a soluble protein involved in signaling, not a structural component like the dense bodies shown in the image. *H band* - The **H band** is located within the **A band** of a **sarcomere** in striated muscle, representing the central region where only thick (myosin) filaments are present. - Similar to the **A band**, the **H band** is a feature of striated muscle and is not found in the unstriated smooth muscle cells.

Q: Which protein plays a role in the process shown below? (Recent NEET Pattern 2018)

Clathrin. ***Clathrin*** - **Clathrin** is the primary protein involved in forming coated pits and vesicles during receptor-mediated endocytosis, which is the process shown in the image. - It forms a characteristic **triskelion structure** (three-legged complex) that assembles into a polyhedral lattice around the budding vesicle. - This protein coat provides the mechanical force needed to bend the membrane and form vesicles for internalizing substances. - Clathrin-mediated endocytosis is the **most well-characterized pathway** for receptor-mediated uptake of molecules. *Pallidin* - Pallidin is a component of the **BLOC-1 complex** (Biogenesis of Lysosome-related Organelles Complex-1). - It is involved in the biogenesis and trafficking of lysosome-related organelles, not in the primary vesicle formation during endocytosis. - Mutations in pallidin cause Hermansky-Pudlak syndrome type 9. *Ubiquitin* - Ubiquitin is a small regulatory protein that marks other proteins for degradation via the **proteasome** or targets them for endocytosis. - While ubiquitination can signal for receptor internalization, ubiquitin itself does not form vesicle coats or directly participate in vesicle budding. *Actin* - Actin is a cytoskeletal protein that plays a supporting role in endocytosis, particularly in membrane invagination and vesicle scission. - It provides mechanical support and force for vesicle movement but is **not the primary coat protein** forming the vesicle structure during initial budding.

Q: Colipase is an enzyme found in secretions from which of the following? (Recent NEET Pattern 2018)

Pancreas. ***Pancreas*** - The pancreas is the primary source of **colipase** secretion in the digestive system. - Colipase is an essential co-factor for **pancreatic lipase**, helping it to anchor to the surface of **lipid droplets** and digest triglycerides in the presence of bile salts. - Colipase is secreted by pancreatic acinar cells along with other pancreatic enzymes into the duodenum. *Salivary glands* - The salivary glands (parotid, submandibular, sublingual) produce saliva containing enzymes like **amylase** and **lingual lipase**. - These glands do not secrete colipase, which is involved in fat digestion in the small intestine, not in the mouth. *Gallbladder* - The gallbladder stores and releases **bile**, which aids in fat emulsification. - Bile does not contain colipase; colipase is produced by the pancreas and works synergistically with bile salts during fat digestion. *Small intestine* - The small intestine is where most nutrient absorption occurs and produces some enzymes (e.g., brush border enzymes like maltase, lactase). - The small intestine does not synthesize colipase; it receives colipase from pancreatic secretions via the pancreatic duct. *Liver* - The liver produces bile, which is stored in the gallbladder and released into the duodenum to emulsify fats. - The liver does not produce colipase; this enzyme is specifically secreted by pancreatic acinar cells.

Q: Sample size of samples A, B and C are 500, 800 and 1000 respectively. Which sample has the highest margin of error? (NEET Jan 2018)

Sample A. ***Sample A*** - The **margin of error** is inversely proportional to the square root of the sample size. Therefore, a smaller sample size leads to a larger margin of error. - Sample A has the smallest sample size (N=500) among the given options, thus having the **highest margin of error**. *Sample B* - With a sample size of 800, Sample B has a **smaller margin of error** than Sample A but a larger margin of error than Sample C. - As the sample size increases, the precision of the estimate improves, and the margin of error decreases. *Sample C* - Sample C has the largest sample size (N=1000), which results in the **smallest margin of error** among all samples. - A larger sample size generally provides a more accurate representation of the population. *None of above* - This option is incorrect because the sample size directly influences the margin of error, and Sample A clearly has the smallest size. - Based on statistical principles, one of the samples must inherently have the highest margin of error.

Q: The program shown in the image is used for monitoring:

TB. ***TB*** - The image shows the **Nikshay** portal logo, which is India's web-based solution for **monitoring and management of Tuberculosis (TB)** patients under the **National Tuberculosis Elimination Programme (NTEP)**, formerly known as RNTCP. - **Nikshay** serves as a comprehensive platform for recording patient data, treatment outcomes, and program performance specifically related to **TB surveillance and control**. *Leprosy* - **Leprosy monitoring** in India is handled through different programs like **NLEP (National Leprosy Eradication Programme)**, not through the Nikshay portal. - The Nikshay system is specifically designed for **TB management**, not for leprosy case detection or monitoring. *OCP usage* - **OCP (Oral Contraceptive Pill)** usage monitoring is part of **family planning programs** and reproductive health initiatives, completely unrelated to infectious disease surveillance. - There is no connection between the **Nikshay portal** and contraceptive usage monitoring systems. *Chandler index* - The **Chandler index** is a forensic pathology measure used to describe **postmortem blood flow changes** in deceased individuals. - It has no relevance to **public health monitoring programs** or disease surveillance systems like Nikshay.

Q: Best drug for the condition shown below is: (NEET Jan 2018)

Doxycycline. ***Correct: Doxycycline*** - The image shows a **tick embedded in the skin** with surrounding erythema, indicative of a **tick bite** and potential **Lyme disease** or other tick-borne infections. - **Doxycycline** is the **drug of choice** for early Lyme disease (caused by *Borrelia burgdorferi*) and many other common tick-borne illnesses like Rickettsial infections (e.g., Rocky Mountain Spotted Fever) and Anaplasmosis. *Incorrect: Ivermectin* - **Ivermectin** is primarily used to treat **parasitic worm infections** like onchocerciasis, strongyloidiasis, and scabies. - It is **not effective** against bacterial infections transmitted by ticks. *Incorrect: Sulphonamides* - **Sulphonamides** are a class of **antibiotics** effective against various bacterial infections, but they are generally **not the first-line treatment** for tick-borne diseases. - For tick-borne illnesses, **doxycycline** typically has broader and more effective coverage. *Incorrect: Penicillin* - **Penicillin** is an **antibiotic** primarily effective against a range of gram-positive and some gram-negative bacteria, and spirochetes like *Treponema pallidum*. - While it has some activity against *Borrelia burgdorferi* (Lyme disease), **doxycycline is preferred** for early-stage Lyme disease and is specifically active against other common tick-borne pathogens where penicillin is not.

Q: Which of the following Schistosoma egg is shown below?

Schistosoma hematobium. ***Schistosoma hematobium*** - The image clearly displays an **elongated, oval-shaped egg** with a characteristic **terminal spine**. - This morphology is pathognomonic for **Schistosoma hematobium**, distinguishing it from other Schistosoma species. *Schistosoma mansoni* - Eggs of *Schistosoma mansoni* are typically **oval-shaped** with a distinct **lateral spine**. - The spine is located on the side of the egg, not at one of its poles as seen in the image. *Schistosoma japonicum* - *Schistosoma japonicum* eggs are more **rounded or oval** and possess a very small, **rudimentary spine** that is often difficult to visualize or absent. - The clearly visible, prominent terminal spine in the image rules out *S. japonicum*. *Cannot be differentiated on wet mount* - The distinct morphological features (shape and spine location) of Schistosoma eggs allow for reliable differentiation on a **wet mount** microscopic examination. - These features are crucial for accurate species identification in laboratory diagnostics.

Q: Choice of drug for management of the parasitic infection shown below is:

Triclabendazole. ***Triclabendazole*** - The image displays an adult **Fasciola hepatica** (liver fluke), characterized by its **leaf-like shape** and the prominent **anterior cone** terminating in an oral sucker. - **Triclabendazole** is the drug of choice for treating **fascioliasis**, as it effectively kills both immature and mature forms of Fasciola hepatica. *Albendazole* - **Albendazole** is primarily used to treat a wide range of **intestinal nematode infections** (e.g., Ascaris, hookworm, whipworm) and some **cestode infections** (e.g., neurocysticercosis, echinococcosis). - It has **limited efficacy** against trematodes like Fasciola hepatica. *Praziquantel* - **Praziquantel** is a broad-spectrum antihelminthic drug effective against most **trematodes (flukes)**, including schistosomes and other liver flukes (e.g., Clonorchis, Opisthorchis), and **cestodes (tapeworms)**. - However, it is **ineffective against Fasciola hepatica**, making it unsuitable for this specific infection. *Niclosamide* - **Niclosamide** is an oral anthelmintic primarily used to treat **tapeworm infections (cestodiasis)**, including Taenia species and Hymenolepis nana. - It is **not effective against trematodes** like Fasciola hepatica.

Q: Which ion plays a role in the process shown below? (Recent NEET Pattern 2018)

Calcium. ***Calcium*** - **Calcium ions (Ca2+)** are the primary trigger for **exocytosis**, binding to **synaptotagmin** proteins on synaptic vesicles to initiate membrane fusion. - Ca2+ influx activates the **SNARE complex** formation, allowing vesicles to fuse with the plasma membrane and release neurotransmitters or other cellular contents. *Potassium* - **Potassium ions (K+)** are primarily responsible for maintaining the **resting membrane potential** and **repolarization** during action potentials. - While essential for neuronal function, K+ does not directly trigger **vesicle fusion** or exocytosis processes. *Sodium* - **Sodium ions (Na+)** are crucial for **action potential depolarization** and maintaining **electrochemical gradients** across cell membranes. - Na+ influx initiates nerve impulses but does not serve as the direct trigger for **vesicle release** during exocytosis. *Magnesium* - **Magnesium ions (Mg2+)** function as essential **cofactors** for numerous enzymes and play roles in **ATP metabolism** and **protein synthesis**. - Although Mg2+ can modulate some cellular processes, it is not the primary ion responsible for triggering **exocytotic release**.

Question 1

Identify the function of the muscles marked in red:

Accepted Answer

Flexion at MCP joint

Answer

Flexion at IP joint

Answer

Extension at MCP joint

Answer

Abduction at MCP joint

Question 2

Which is correct about structures marked as "X" found in smooth muscle?

Accepted Answer

Dense bodies

Answer

A band

Answer

Calmodulin

Answer

H band

Question 3

Which protein plays a role in the process shown below? (Recent NEET Pattern 2018)

Accepted Answer

Clathrin

Answer

Ubiquitin

Answer

Pallidin

Answer

Actin

Question 4

Colipase is an enzyme found in secretions from which of the following? (Recent NEET Pattern 2018)

Accepted Answer

Pancreas

Answer

Salivary glands

Answer

Gallbladder

Answer

Small intestine

Answer

Liver

Question 5

Sample size of samples A, B and C are 500, 800 and 1000 respectively. Which sample has the highest margin of error? (NEET Jan 2018)

Accepted Answer

Sample A

Answer

Sample B

Answer

Sample C

Answer

None of above

Question 6

The program shown in the image is used for monitoring:

Accepted Answer

TB

Answer

OCP usage

Answer

Chandler index

Answer

Leprosy

Question 7

Best drug for the condition shown below is: (NEET Jan 2018)

Accepted Answer

Doxycycline

Answer

Ivermectin

Answer

Sulphonamides

Answer

Penicillin

Question 8

Which of the following Schistosoma egg is shown below?

Accepted Answer

Schistosoma hematobium

Answer

Schistosoma mansoni

Answer

Schistosoma japonicum

Answer

Cannot be differentiated on wet mount

Question 9

Choice of drug for management of the parasitic infection shown below is:

Accepted Answer

Triclabendazole

Answer

Albendazole

Answer

Praziquantel

Answer

Niclosamide

Question 10

Which ion plays a role in the process shown below? (Recent NEET Pattern 2018)

Accepted Answer

Calcium

Answer

Potassium

Answer

Sodium

Answer

Magnesium

NEET-PG 2018

Anatomy

Biochemistry

Community Medicine

Dermatology

Microbiology

Pharmacology

Physiology