Colipase is an enzyme found in secretions from which of the following? (Recent NEET Pattern 2018)

Pancreas. ***Pancreas*** - The pancreas is the primary source of **colipase** secretion in the digestive system. - Colipase is an essential co-factor for **pancreatic lipase**, helping it to anchor to the surface of **lipid droplets** and digest triglycerides in the presence of bile salts. - Colipase is secreted by pancreatic acinar cells along with other pancreatic enzymes into the duodenum. *Salivary glands* - The salivary glands (parotid, submandibular, sublingual) produce saliva containing enzymes like **amylase** and **lingual lipase**. - These glands do not secrete colipase, which is involved in fat digestion in the small intestine, not in the mouth. *Gallbladder* - The gallbladder stores and releases **bile**, which aids in fat emulsification. - Bile does not contain colipase; colipase is produced by the pancreas and works synergistically with bile salts during fat digestion. *Small intestine* - The small intestine is where most nutrient absorption occurs and produces some enzymes (e.g., brush border enzymes like maltase, lactase). - The small intestine does not synthesize colipase; it receives colipase from pancreatic secretions via the pancreatic duct. *Liver* - The liver produces bile, which is stored in the gallbladder and released into the duodenum to emulsify fats. - The liver does not produce colipase; this enzyme is specifically secreted by pancreatic acinar cells. [Practice more Biochemistry PYQs on OnCourse]

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