Which of the following is a characteristic of Wilson's disease?
The most common cause of pontine hemorrhage is
Thrombotic thrombocytopenic purpura is a syndrome characterized by which of the following?
Primary hyperparathyroidism is suggested by all of the following, except which of the following?
Which of the following is not a feature of Systemic Lupus Erythematosus (SLE)?
Antibodies most commonly seen in drug induced lupus are:
Which of the following is a characteristic feature of Crohn's disease?
What is a feature of short bowel syndrome?
In a patient with acute cholecystitis, referred pain to the shoulder is known as
In Marfan's syndrome, Aortic aneurysm occurs most commonly in:
NEET-PG 2012 - Internal Medicine NEET-PG Practice Questions and MCQs
Question 81: Which of the following is a characteristic of Wilson's disease?
- A. Increased copper in liver (Correct Answer)
- B. Autosomal dominant
- C. Increased serum ceruloplasmin
- D. Decreased copper excretion in urine
Explanation: ***Increased copper in liver*** - Wilson's disease is characterized by **accumulation of copper** in liver tissues due to defective copper transport [1]. - This excess leads to **hepatocellular damage**, resulting in liver dysfunction and potential cirrhosis [1]. *Decreased copper excretion in urine* - In Wilson's disease, there is actually **decreased excretion of copper**, which results in accumulation in the liver [1]. - **Urine copper levels** are typically low to normal in early stages because the liver fails to excrete excess copper effectively. *Autosomal dominant* - Wilson's disease is inherited in an **autosomal recessive** pattern, not dominant. - It is caused by mutations in the gene responsible for copper transport (ATP7B) [1]. *Increased serum ceruloplasmin* - Serum ceruloplasmin levels are often **decreased** in Wilson's disease due to impaired copper incorporation into this protein [1]. - Low ceruloplasmin is a key laboratory finding, contrasting the assertion of this option.
Question 82: The most common cause of pontine hemorrhage is
- A. Hypertension (Correct Answer)
- B. Diabetes
- C. Trauma
- D. Aneurysmal rupture
Explanation: Hypertension - **Chronic hypertension** leads to the weakening and rupture of small perforating arteries in the pons, making it the most common cause of **pontine hemorrhage** [1]. - The elevated pressure damages the **endothelium** and smooth muscle layers of these vessels, predisposing them to bleeding. *Diabetes* - While diabetes can cause microvascular complications, it is not considered the most common cause of **pontine hemorrhage**. - Its primary cerebral vascular complications include increased risk of **ischemic stroke** rather than hemorrhagic stroke in the pons. *Trauma* - **Traumatic brain injury** can cause various types of intracranial hemorrhage, but isolated **pontine hemorrhage** directly due to trauma is less common than that due to hypertension [1]. - Trauma typically results in contusions, subdural, or epidural hematomas, often in superficial brain regions. *Aneurysmal rupture* - **Aneurysmal rupture** is a common cause of subarachnoid hemorrhage, particularly from the Circle of Willis, but pontine hemorrhages are rarely caused by aneurysms within the pons itself [1]. - The vessels supplying the pons are typically small and perforating, not commonly forming dissecting or saccular aneurysms.
Question 83: Thrombotic thrombocytopenic purpura is a syndrome characterized by which of the following?
- A. Thrombocytopenia, anemia, neurological abnormalities, progressive renal failure and fever (Correct Answer)
- B. Thrombocytopenia, anemia, neurological abnormalities, progressive hepatic failure and fever
- C. Thrombocytopenia, normal anemia, neurological abnormalities, progressive renal failure and fever
- D. Thrombocytopenia, anemia, no neurological abnormalities, progressive renal failure and fever
Explanation: ***Thrombocytopenia, anemia, neurological abnormalities, progressive renal failure and fever*** - Thrombotic thrombocytopenic purpura is characterized by **thrombocytopenia** and **microangiopathic hemolytic anemia**, along with neurological and renal complications [1][2]. - The presence of **fever** and other systemic symptoms is consistent with this **thrombotic microangiopathy** syndrome [1]. *Thrombocytosis, anemia, neurologic abnormalities, progressive renal failure and fever* - This option incorrectly lists **thrombocytosis** rather than **thrombocytopenia**, which is a hallmark of thrombotic thrombocytopenic purpura (TTP) [1]. - While it includes anemia, the absence of thrombocytopenia makes it inconsistent with TTP's classic presentation [2]. *Thrombocytopenia, anemia, neurologic abnormalities, progressive hepatic failure and fever* - Although it correctly states **thrombocytopenia** and **anemia**, it incorrectly identifies **progressive hepatic failure** instead of **renal failure**, which is a key feature of TTP [1]. - The presence of neurological abnormalities and fever does align with TTP; however, the hepatic failure aspect is misleading. *Thrombocytosis, anemia neurologic abnormalities, progressive renal failure and fever* - Again, this option incorrectly notes **thrombocytosis**, contradicting the characteristic finding of **thrombocytopenia** found in TTP [1]. - While other features align with TTP's clinical picture, the thrombocytosis excludes this option from being correct [2]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Kidney, pp. 947-948. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Red Blood Cell and Bleeding Disorders, pp. 667-668.
Question 84: Primary hyperparathyroidism is suggested by all of the following, except which of the following?
- A. Increased serum calcium
- B. Low urinary calcium levels (Correct Answer)
- C. Increased urinary calcium
- D. Decreased PTH levels
Explanation: ***Low urinary calcium*** - In primary hyperparathyroidism, **urinary calcium levels are typically elevated** due to increased calcium reabsorption in the kidneys [2]. - **Low urinary calcium levels** would suggest a different condition, such as **hypoparathyroidism** or a renal issue affecting calcium excretion [5]. *Increased PTH* - Primary hyperparathyroidism is characterized by **elevated parathyroid hormone (PTH)** levels, as the parathyroid glands are overactive [1][3]. - High PTH contributes to increased serum calcium and bone resorption [2]. *Increased serum calcium* - A hallmark of primary hyperparathyroidism is **hypercalcemia**, resulting from increased bone resorption and renal tubular reabsorption of calcium [1][2]. - The condition often leads to symptoms such as **kidney stones** and **bone pain** due to elevated serum calcium levels [3][4]. *Increased C-AMP* - Elevated levels of **cyclic AMP (C-AMP)** in urine are observed in primary hyperparathyroidism due to the stimulatory effect of PTH on renal tubular reabsorption of calcium. - Increased C-AMP correlates with the action of PTH in promoting calcium release from the bones [2].
Question 85: Which of the following is not a feature of Systemic Lupus Erythematosus (SLE)?
- A. Recurrent abortion
- B. Sterility (Correct Answer)
- C. Psychosis
- D. Coomb's positive hemolytic anemia
Explanation: ***Sterility*** - While SLE can affect fertility due to **gonadal dysfunction** or **treatment-related factors**, it is not a *direct* or *defining feature* of the disease itself. - Sterility is a less common manifestation compared to the widespread organ system involvement that characterizes SLE [2]. *Recurrent abortion* - **Recurrent abortions** are a well-recognized complication in SLE, particularly when associated with **antiphospholipid syndrome**, which frequently co-occurs with SLE [1]. - **Antiphospholipid antibodies** can lead to thrombosis in placental vessels, causing fetal loss. *Psychosis* - **Psychosis** is a significant neuropsychiatric manifestation of SLE, classified under **neuropsychiatric lupus (NPSLE)**. - It can result from **inflammation**, **autoantibody effects**, or **ischemia** within the central nervous system. *Coomb's positive hemolytic anemia* - **Coomb's positive hemolytic anemia** is a common hematological complication in SLE, indicating the presence of **autoantibodies** against red blood cells [3]. - This **autoimmune destruction** of red blood cells leads to anemia, and a positive direct Coombs test confirms antibody sensitization [3].
Question 86: Antibodies most commonly seen in drug induced lupus are:
- A. Anti ds DNA Antibodies
- B. Anti Sm Antibodies
- C. Anti-Ro Antibodies
- D. Antihistone Antibodies (Correct Answer)
Explanation: ***Antihistone Antibodies*** - **Antihistone antibodies** are the most common laboratory finding, present in 95% of patients with **drug-induced lupus erythematosus (DIL)**. - This type of lupus is often triggered by medications such as **procainamide**, **hydralazine**, and **isoniazid**. *Anti ds DNA Antibodies* - **Anti-double-stranded DNA (dsDNA) antibodies** are highly specific for **systemic lupus erythematosus (SLE)**, particularly severe cases, but are rarely seen in DIL. - High titers of anti-dsDNA often correlate with **lupus nephritis** and disease activity. *Anti Sm Antibodies* - **Anti-Sm antibodies** are highly specific for **SLE**, sometimes associated with neuropsychiatric manifestations, but are rarely identified in drug-induced lupus. - Their presence helps to confirm the diagnosis of SLE but not DIL. *Anti-Ro Antibodies* - **Anti-Ro (SSA) antibodies** are most commonly associated with **Sjögren's syndrome** and **neonatal lupus**, and can be seen in a subset of SLE patients, especially those with photosensitivity. - While they can be present in some forms of SLE, they are not the hallmark autoantibody for drug-induced lupus.
Question 87: Which of the following is a characteristic feature of Crohn's disease?
- A. Sinus & fistula (Correct Answer)
- B. Mesenteric lymphadenitis
- C. Continuous involvement
- D. Crypt abscesses
Explanation: ***Sinus & fistula*** - **Transmural inflammation**, a hallmark of Crohn's disease, can extend through the bowel wall, leading to the formation of **sinus tracts** and **fistulae** (abnormal connections between organs or to the skin). [1] - These complications include enteroenteric, enterovesical, and perianal fistulae, which are highly characteristic of Crohn's. [1] *Continuous involvement* - Crohn's disease is characterized by **skip lesions**, meaning there are healthy segments of bowel interspersed with diseased segments, not continuous involvement. [1] - **Ulcerative colitis** typically presents with continuous inflammation, starting from the rectum and extending proximally. [1] *Mesenteric lymphadenitis* - While mesenteric lymph nodes can be involved in Crohn's disease due to inflammation, **mesenteric lymphadenitis** is more commonly associated with infectious etiologies or other inflammatory conditions, and not a primary defining characteristic. - It refers to inflammation of lymph nodes in the mesentery, which can cause abdominal pain but does not specifically differentiate Crohn's from other conditions. *Crypt abscesses* - **Crypt abscesses** are a characteristic histological feature of **ulcerative colitis**, where neutrophils infiltrate the glandular crypts. [1] - While they can occasionally be seen in Crohn's, they are much more common and prominent in ulcerative colitis and are not a defining feature of Crohn's.
Question 88: What is a feature of short bowel syndrome?
- A. Hypergastrinemia & high gastric secretion is seen
- B. Diarrhea, dehydration and malnutrition
- C. Chronic TPN dependence
- D. Malabsorption leading to diarrhea, dehydration, and malnutrition. (Correct Answer)
Explanation: ***Malabsorption leading to diarrhea, dehydration, and malnutrition.*** [1], [2] - The primary characteristic of short bowel syndrome is **reduced intestinal surface area**, leading to inadequate absorption of nutrients, water, and electrolytes [1]. - This malabsorption manifests as **chronic diarrhea**, which can cause significant **dehydration** and **malnutrition** due to nutrient deficiencies [2]. *Diarrhea, dehydration and malnutrition* - While these are prominent symptoms, they are consequences of the underlying **malabsorption**, which is the fundamental process. - This option describes symptoms but doesn't fully explain the root physiological mechanism as comprehensively as the correct answer. *Chronic TPN dependence* - **Total Parenteral Nutrition (TPN)** dependence can be a severe consequence for patients with very short or severely damaged bowel segments, but it is not a feature inherent to all cases of short bowel syndrome. - Many patients can manage with oral or enteral nutrition, especially if a significant portion of the small bowel remains functional. *Hypergastrinemia & high gastric secretion is seen* - This can occur in certain cases of short bowel syndrome, particularly if there is a loss of the **duodenum** (which normally inhibits gastrin release) or if there's extensive ileal resection. - However, it's not a universal or defining feature for all patients and is secondary to the primary problem of malabsorption.
Question 89: In a patient with acute cholecystitis, referred pain to the shoulder is known as
- A. Murphy's sign
- B. Gray Turner sign
- C. Boas' sign (Correct Answer)
- D. Cullen's sign
Explanation: ***Boas' sign*** - **Boas' sign** refers to the presence of hyperesthesia below the right scapula, which can also manifest as referred pain to the **right shoulder** or back [1]. - This symptom in acute cholecystitis is due to the **irritation** of the **phrenic nerve**, which shares sensory pathways with the shoulder region. *Murphy's sign* - **Murphy's sign** is elicited by asking the patient to exhale, then placing the examiner's hand below the costal margin on the right mid-clavicular line, and then asking the patient to inhale deeply [1]. - A positive sign is indicated by a sudden cessation of inspiration due to pain, which is specific for **acute cholecystitis** and not referred shoulder pain [1]. *Gray Turner sign* - The **Gray Turner sign** involves ecchymosis or discoloration of the flanks. - It is a severe indicator of **retroperitoneal hemorrhage**, often associated with acute pancreatitis, not cholecystitis [2]. *Cullen's sign* - **Cullen's sign** presents as periumbilical ecchymosis or discoloration around the navel. - This sign is also indicative of **retroperitoneal hemorrhage**, typically seen in serious conditions like ruptured ectopic pregnancy or acute pancreatitis.
Question 90: In Marfan's syndrome, Aortic aneurysm occurs most commonly in:
- A. Ascending aorta (Correct Answer)
- B. Descending aorta
- C. Abdominal aorta
- D. Arch of aorta
Explanation: ***Ascending aorta*** - The **ascending aorta** is the most common site for aortic aneurysm and dissection in Marfan syndrome due to cystic medial degeneration weakening the vessel wall [1]. - This predisposition is linked to defects in the **fibrillin-1 gene (FBN1)**, severely impacting the structural integrity of the arterial media primarily in the ascending aorta [1]. *Descending aorta* - While possible, **descending aortic** involvement is less common than ascending aortic involvement in Marfan syndrome [2]. - Aneurysms here are more frequently associated with atherosclerosis or other connective tissue disorders. *Abdominal aorta* - **Abdominal aortic aneurysms** are relatively rare in Marfan syndrome and are more typically seen in older patients with atherosclerosis [3]. - The disease primarily affects the elastic tissue content, which is most abundant in the proximal aorta. *Arch of aorta* - Aortic arch aneurysms can occur, but they are still less frequent than those in the **ascending aorta** as the primary initial site of dilation and dissection in Marfan syndrome. - Arch involvement often represents an extension of a more proximal ascending aortic pathology.