Which of the following complications is commonly associated with mitral valve prolapse?
Progressive distal-to-proximal motor recovery following nerve regeneration is most characteristic of which type of nerve injury?
Which of the following is the most characteristic symptom of obstruction of the inferior vena cava?
In which condition is venous blood most commonly observed to have a high hematocrit in routine clinical practice?
Which of the following is an acquired condition?
What is the most common cause of dissecting hematoma?
Which components of cigarette smoke are known to contribute to coronary artery disease?
Creola bodies are seen in:
Which condition is most commonly associated with systemic amyloidosis?
Which condition is commonly associated with Disseminated Intravascular Coagulation (D.I.C.)?
NEET-PG 2012 - Internal Medicine NEET-PG Practice Questions and MCQs
Question 11: Which of the following complications is commonly associated with mitral valve prolapse?
- A. Ventricular arrhythmia
- B. Stroke
- C. Infective endocarditis (Correct Answer)
- D. Mitral stenosis
Explanation: Mitral valve prolapse (MVP) involves myxomatous degeneration of the mitral valve leaflets, which can create a rough surface predisposing to bacterial adhesion and subsequent infective endocarditis [1]. While the overall risk is low, patients with MVP and accompanying mitral regurgitation or thickened leaflets are at higher risk [1]. Patients with valvular heart disease are generally susceptible to bacterial endocarditis, often associated with procedures or dental hygiene [2]. Stroke - Although MVP can sometimes be associated with embolic events (e.g., from thrombi forming on the prolapsing valve), stroke is not considered a commonly associated complication. - The risk of stroke is generally higher in MVP patients with concomitant atrial fibrillation or other cardiovascular risk factors. Mitral stenosis - Mitral valve prolapse is characterized by the displacement of mitral valve leaflets into the left atrium during systole, which can lead to mitral regurgitation [3], not stenosis. - Mitral stenosis involves narrowing of the mitral valve orifice, usually due to rheumatic fever, which is a different pathophysiology [4]. Ventricular arrhythmia - While palpitations (often benign supraventricular ectopy) are common in MVP, clinically significant ventricular arrhythmias are less common. - Severe ventricular arrhythmias are more typically seen with significant underlying myocardial disease or severe mitral regurgitation causing left ventricular dysfunction.
Question 12: Progressive distal-to-proximal motor recovery following nerve regeneration is most characteristic of which type of nerve injury?
- A. Axonotmesis (Correct Answer)
- B. Neurotmesis
- C. Neuropraxia
- D. Nerve injury
Explanation: ***Axonotmesis*** - Involves damage to the **axon** and myelin sheath, while the surrounding **epineurium** remains intact. - This preservation of the connective tissue allows for guided **regeneration** of axons from distal to proximal, leading to a good prognosis for recovery [1]. *Neurotmesis* - Refers to the **complete transection** of the nerve, including the axon, myelin, and all connective tissue sheaths. - Recovery is often **incomplete** or requires surgical repair, as significant misdirection of regenerating axons is common. *Neuropraxia* - Characterized by a **temporary block** in nerve conduction, typically due to **demyelination**, with the axon remaining intact. - Recovery is usually **rapid** and complete, occurring within days to weeks, as no axonal regeneration is needed. *Nerve injury* - This is a **general term** that encompasses all types of nerve damage, from mild to severe. - It does not specify a particular mechanism or pattern of recovery, making it less precise than the more specific classifications.
Question 13: Which of the following is the most characteristic symptom of obstruction of the inferior vena cava?
- A. Paraumblical dilatation (Correct Answer)
- B. Thoraco-epigastric dilatation
- C. Haemorrhoides
- D. Oesophageal varices
Explanation: ***Paraumbilical dilatation*** - Obstruction of the **inferior vena cava (IVC)** leads to collateral circulation through superficial veins, especially around the umbilicus, causing **paraumbilical dilatation** (caput medusae). - This collateral flow bypasses the obstructed IVC to return blood to the superior vena cava system. *Thoraco-epigastric dilatation* - This pattern of collateral circulation is more characteristic of **superior vena cava (SVC) obstruction**, where blood from the upper body needs to bypass the SVC. - The dilated veins would typically be seen on the chest and upper abdomen, draining towards the femoral veins. *Oesophageal varices* - **Oesophageal varices** are typically caused by **portal hypertension** [1], often secondary to liver cirrhosis, not directly by IVC obstruction. - They represent portosystemic collateral veins, diverging from the portal system to the systemic circulation [1]. *Haemorrhoids* - **Haemorrhoids** are dilated veins in the anal canal, most commonly caused by **straining** during defecation or conditions that increase intra-abdominal pressure [2]. - While they can be a sign of portal hypertension [1], **IVC obstruction** is not their primary or most characteristic cause.
Question 14: In which condition is venous blood most commonly observed to have a high hematocrit in routine clinical practice?
- A. Dehydration (Correct Answer)
- B. Anemia
- C. Hypervolemia
- D. Acute blood loss
Explanation: Dehydration - In **dehydration**, the total body water is reduced, leading to a decrease in plasma volume [1, 5]. This concentrates the red blood cells, resulting in a relatively **high hematocrit**. [3] - This is a common finding as the body attempts to conserve fluid, making it a primary cause of **elevated hematocrit** in clinical practice. *Anemia* - **Anemia** is characterized by a decrease in the number of red blood cells or a reduced hemoglobin concentration, which would lead to a **low hematocrit**, not a high one [2]. - This condition involves insufficient oxygen-carrying capacity due to a deficiency in red blood cells or hemoglobin [2]. *Hypervolemia* - **Hypervolemia** describes an excess of fluid in the blood, which would dilute the blood components, leading to a relatively **low hematocrit** [1]. - This condition is often associated with conditions like heart failure or kidney disease, where fluid retention is common. *Acute blood loss* - In **acute blood loss**, the loss of whole blood immediately after the event would initially reduce both red blood cells and plasma proportionally, not immediately raising hematocrit [2]. - As the body attempts to compensate by shifting extravascular fluid into the circulation, this would further dilute the blood, eventually leading to a **decreased hematocrit** [2].
Question 15: Which of the following is an acquired condition?
- A. Polymastia (supernumerary breasts)
- B. Polythelia (extra nipples)
- C. Mastitis (Correct Answer)
- D. Amastia (absence of breast tissue)
Explanation: ***Mastitis*** - **Mastitis** is an **inflammatory condition** of the breast, often caused by bacterial infection, particularly common during **lactation** [1]. - It is an **acquired condition** as it develops after birth due to external or internal factors, not present at birth. *Polymastia (supernumerary breasts)* - **Polymastia** is a **congenital condition** where additional breast tissue develops along the **milk line**. - This condition is present at birth and results from *embryological development anomalies*, not acquired later in life. *Polythelia (extra nipples)* - **Polythelia** refers to the presence of **accessory nipples** along the embryonic milk line and is a **congenital anomaly**. - Like polymastia, it is present from birth due to *developmental errors* and is not an acquired condition. *Amastia (absence of breast tissue)* - **Amastia** is a rare **congenital anomaly** characterized by the complete absence of breast tissue, nipple, and areola. - It is a **birth defect**, meaning it is present from birth and not an acquired condition.
Question 16: What is the most common cause of dissecting hematoma?
- A. Hypertension (Correct Answer)
- B. Marfan syndrome
- C. Iatrogenic causes
- D. Kawasaki disease
Explanation: ***Hypertension*** - **Chronic hypertension** is the most frequent cause of dissecting hematoma (aortic dissection) due to the constant high pressure stressing the arterial wall [1]. - It leads to **medial degeneration** and predisposition to intimal tear, allowing blood to enter the arterial wall [1]. *Marfan syndrome* - While Marfan syndrome is a significant risk factor for aortic dissection due to **connective tissue weakness** (cystic medial necrosis), it is much less common than hypertension [1]. - It primarily affects younger individuals with a genetic predisposition to **fibrillin-1 mutations**. *Iatrogenic causes* - These include complications from medical procedures like **cardiac catheterization** or surgery [1]. - Though a possible cause, iatrogenic dissection is relatively rare compared to spontaneous dissection due to hypertension [1]. *Kawasaki disease* - Kawasaki disease primarily causes **coronary artery aneurysms** in children. - It is not a common cause of aortic dissecting hematoma in adults.
Question 17: Which components of cigarette smoke are known to contribute to coronary artery disease?
- A. Nicotine, carbon monoxide, and tar (Correct Answer)
- B. Carbon monoxide and tar
- C. Carbon dioxide
- D. Tar and nicotine
Explanation: ***Nicotine, carbon monoxide, and tar*** - **Nicotine** directly affects the cardiovascular system by increasing **heart rate**, **blood pressure**, and causing **vasoconstriction**, as well as promoting atherogenesis [2]. - **Carbon monoxide** binds to hemoglobin with higher affinity than oxygen, forming **carboxyhemoglobin**, which reduces oxygen delivery to tissues, leading to **endothelial damage** and contributing to atherosclerosis [1]. - **Tar** contains various **carcinogens** and toxic chemicals that contribute to inflammation, oxidative stress, and lipid peroxidation, all of which are implicated in the development and progression of **atherosclerosis**. *Carbon monoxide and tar* - While both contribute significantly, this option **omits nicotine**, which is a major contributor to the cardiovascular effects of smoking. - Nicotine's direct impact on **vasoconstriction** and **atherogenesis** is a critical factor in coronary artery disease [2]. *Carbon dioxide* - **Carbon dioxide** is a product of respiration and combustion but is not considered a primary direct contributor to the pathogenesis of **coronary artery disease** from cigarette smoke in the same way as nicotine, carbon monoxide, and tar. - Its presence in smoke primarily relates to its role in **respiratory physiology** rather than direct vascular damage. *Tar and nicotine* - This option correctly identifies **tar** and **nicotine** as contributors but **omits carbon monoxide**, which plays a crucial role in reducing oxygen-carrying capacity and directly damaging the endothelium [1]. - The impact of **carbon monoxide** on cardiac oxygen supply is a significant mechanism in smoking-related cardiovascular disease [1].
Question 18: Creola bodies are seen in:
- A. Emphysema
- B. Chronic bronchitis
- C. Bronchiectasis
- D. Bronchial asthma (Correct Answer)
Explanation: ***Bronchial asthma*** - **Creola bodies** are clusters of **desquamated columnar epithelial cells** found in the sputum of patients with asthma. [1] - Their presence indicates ongoing **bronchial inflammation** and epithelial damage, characteristic of asthma exacerbations. *Chronic bronchitis* - Characterized by **mucus hypersecretion** and **chronic productive cough**, without the specific finding of Creola bodies. - Histologically, it involves **goblet cell hyperplasia** and **mucous gland enlargement**. *Emphysema* - Defined by irreversible enlargement of airspaces distal to the terminal bronchioles with **destruction of alveolar walls**, not specific cell aggregates. [1] - The primary defect is loss of **elastic recoil** and **airflow limitation**. *Bronchiectasis* - Involves **permanent abnormal dilation** of the bronchi due to destruction of the muscular and elastic components of the bronchial wall. [1] - Sputum typically contains inflammatory cells and bacteria, but Creola bodies are not a defining feature.
Question 19: Which condition is most commonly associated with systemic amyloidosis?
- A. Chronic Kidney Disease (Correct Answer)
- B. Multiple Myeloma
- C. Rheumatoid Arthritis
- D. Familial Mediterranean Fever
Explanation: Type II DM - Amyloidosis is commonly associated with **chronic diseases** like type II diabetes mellitus due to insulin resistance leading to amyloid deposition [4]. - The presence of **amiloid in the pancreas** often correlates with the complications of this type of diabetes [3]. *Maturity onset DM* - While maturity-onset diabetes can lead to complications, it is often synonymous with **type II DM**, making this distinction inaccurate regarding amyloidosis. - This term is less commonly used and does not emphasize the direct link to amyloidosis seen in type II diabetes. *HTN* - Hypertension itself is not a direct cause of amyloidosis; it typically results from other underlying conditions. - The association of amyloidosis with hypertension is usually **secondary**, not a primary condition leading to amyloid deposits [2]. *Type I DM* - Type I diabetes is primarily **autoimmune**, resulting in insulin-deficient states and does not strongly associate with amyloidosis like type II [1]. - The amyloid deposits seen in type I are much less common compared to type II or associated chronic conditions.
Question 20: Which condition is commonly associated with Disseminated Intravascular Coagulation (D.I.C.)?
- A. Acute myelomonocytic leukemia
- B. Chronic myeloid leukemia
- C. Autoimmune hemolytic anemia
- D. Acute promyelocytic leukemia (Correct Answer)
Explanation: ***Acute promyelocytic leukemia*** - **Disseminated Intravascular Coagulation (D.I.C.)** is commonly associated with acute promyelocytic leukemia due to the release of **tissue factor** from promyelocytes [1]. - Patients typically present with **severe bleeding** and coagulopathy [1], driven by the rapid proliferation of these abnormal cells. *Acute myelomonocytic leukemia* - While this type of leukemia presents with myelomonocytic features, it is less frequently associated with **D.I.C.** compared to acute promyelocytic leukemia. - This condition is often characterized by **monocytic infiltration** but does not typically cause the severe coagulopathy associated with D.I.C. *Autoimmune hemolytic anemia* - This condition causes **hemolysis** due to antibodies but is mainly associated with **anemia**, not a coagulation disorder like D.I.C. - **D.I.C.** involves widespread **consumption coagulopathy** [1], which is not a feature of autoimmune hemolytic anemia. *CMC* - CMC refers to **Chronic Myeloid Leukemia**, which does not commonly lead to **D.I.C.** and presents primarily with splenomegaly and **chronic symptoms**. - The coagulation profile in CMC tends to be stable, with no link to the acute coagulopathy seen in D.I.C.