Biochemistry
2 questionsWhat is the role of Anandamide in the human body?
Which of the following is not an acute phase reactant?
NEET-PG 2013 - Biochemistry NEET-PG Practice Questions and MCQs
Question 551: What is the role of Anandamide in the human body?
- A. Opioid
- B. D2 blocker
- C. Cannabinoid neurotransmitter (Correct Answer)
- D. CCK1 antagonist
Explanation: ***Cannabinoid neurotransmitter*** - **Anandamide** is an **endogenous cannabinoid neurotransmitter** that binds to **CB1** and **CB2 receptors**. - It plays a role in **pain modulation**, **appetite stimulation**, and **memory regulation**. *Opioid* - **Opioids** bind to **opioid receptors** (mu, delta, kappa) and are known for their **analgesic** and **euphoric effects**. - Examples include **morphine** and **endorphins**, which are chemically distinct from anandamide and have different receptor targets. *CK 1 antagonist* - This option refers to a **cholecystokinin 1 (CCK1) receptor antagonist**, which would block the effects of **CCK**. - **CCK** is a hormone involved in **digestion** and **satiety**, and its role is unrelated to anandamide. *D2 blocker* - A **D2 blocker** is an agent that antagonizes the **dopamine D2 receptor**. - These are typically **antipsychotic medications** that modulate **dopamine pathways** in the brain, unrelated to the function of anandamide.
Question 552: Which of the following is not an acute phase reactant?
- A. C-reactive protein
- B. Haptoglobin
- C. Endothelin (Correct Answer)
- D. Fibrinogen
Explanation: ***Endothelin*** - Endothelin is a **vasoconstrictive peptide** primarily involved in regulating **blood vessel tone** and blood pressure. - While it plays a role in processes like inflammation and tissue repair, it is not synthesized or regulated in the same rapid, systemic manner as a classic acute phase reactant. *C-reactive protein* - **C-reactive protein (CRP)** is a rapidly responding acute phase reactant produced by the liver in response to **inflammation**, infection, and tissue injury. - Its levels can rise dramatically within hours of an inflammatory stimulus and are used as a marker for disease activity. *Haptoglobin* - **Haptoglobin** is an acute phase reactant that binds to free **hemoglobin** released from red blood cells during hemolysis, preventing oxidative damage. - Its levels typically increase during acute inflammation or infection, although it can also decrease with severe hemolysis. *Fibrinogen* - **Fibrinogen** is a critical acute phase protein involved in the **coagulation cascade** and wound healing. - Its concentration increases significantly during acute inflammation, contributing to the elevated **erythrocyte sedimentation rate (ESR)**.
Community Medicine
1 questionsMost important component of level of living is
NEET-PG 2013 - Community Medicine NEET-PG Practice Questions and MCQs
Question 551: Most important component of level of living is
- A. Education
- B. Housing
- C. Health
- D. Occupation (Correct Answer)
Explanation: ***Occupation*** - **Occupation** is the most important component of the level of living as it is the primary determinant of **income**, which forms the economic foundation of the level of living. - In Community Medicine, "level of living" is an **objective economic indicator** primarily measured by income and consumption patterns, distinguishing it from the broader concept of "quality of life." - A stable and remunerative occupation ensures regular income, which directly enables individuals to afford basic necessities (food, clothing, shelter) and access other essential resources like healthcare and education. - Occupation also confers social status and determines the standard of living that an individual or family can maintain. *Education* - While **education** is crucial for human development and enhances future opportunities, it serves as a means to achieve better employment rather than being a direct component of the level of living itself. - Education's impact on living standards is realized primarily through its influence on occupational opportunities and earning potential. *Housing* - **Housing** is an important indicator of living standards and reflects the level of living, but the quality and affordability of housing are dependent on income derived from occupation. - It is more of an outcome of the level of living rather than its primary determinant. *Health* - **Health** is essential for well-being and productivity, but in the context of "level of living" as an economic measure, it is often a consequence of adequate income and access to resources (which stem from occupation) rather than the primary component. - Good health enables productivity, but health status alone does not define the economic level of living without associated income security.
Pharmacology
4 questionsWhich of the following drugs can cause thyroid dysfunction?
What serious side effect may lead to the discontinuation of felbamate?
Which of the following statements about lamotrigine is correct?
Visual field monitoring is important before starting which of the following drugs for epilepsy treatment?
NEET-PG 2013 - Pharmacology NEET-PG Practice Questions and MCQs
Question 551: Which of the following drugs can cause thyroid dysfunction?
- A. Amiodarone (Correct Answer)
- B. Ampicillin
- C. Ibutilide
- D. Acyclovir
Explanation: ***Amiodarone*** - **Amiodarone** is known to cause both **hypothyroidism** and **hyperthyroidism** due to its high iodine content and direct toxic effects on the thyroid gland. - Its effects can persist for months after discontinuation due to its **long half-life** and accumulation in tissues. *Ampicillin* - **Ampicillin** is an antibiotic that generally does not directly affect thyroid function. - Its primary mechanism of action involves inhibiting **bacterial cell wall synthesis**, with no known significant endocrine side effects. *Ibutilide* - **Ibutilide** is an antiarrhythmic drug used for recent-onset atrial fibrillation or flutter. - It works by blocking potassium channels and has no recognized association with thyroid dysfunction. *Acyclovir* - **Acyclovir** is an antiviral medication used to treat herpes virus infections. - Its mechanism of action involves inhibiting viral DNA replication and it is not known to impact thyroid hormone synthesis or metabolism.
Question 552: What serious side effect may lead to the discontinuation of felbamate?
- A. Seizures
- B. Renal impairment
- C. Gastrointestinal disorder
- D. Aplastic anemia (Correct Answer)
Explanation: ***Aplastic anemia*** - Felbamate is known to cause **aplastic anemia**, a severe and life-threatening condition where the **bone marrow stops producing enough new blood cells**. - Felbamate carries a **black box warning** for both aplastic anemia and **hepatotoxicity (severe liver failure)**, which are the two most serious adverse effects leading to discontinuation. - Due to this significant risk, felbamate is reserved for severe, refractory epilepsy cases, and patients require **regular monitoring** of blood counts and liver function tests. *Renal impairment* - While some medications can cause renal impairment, **felbamate is not primarily associated** with this side effect to the extent of requiring discontinuation. - Its metabolism and excretion are predominantly **hepatic (liver)**, and renal effects are less common or severe. *Gastrointestinal disorder* - Gastrointestinal side effects like nausea or vomiting are **common with many medications**, including felbamate, but are generally **mild and manageable**, rarely leading to discontinuation. - These effects are usually **dose-dependent** and can often be mitigated with supportive care. *Seizures* - Felbamate is an **antiepileptic drug (AED)**, so it is used to treat seizures, not cause them. - If a patient experiences seizures while on felbamate, it usually indicates **inadequate treatment response** or seizure exacerbation, rather than a direct side effect necessitating discontinuation for toxicity.
Question 553: Which of the following statements about lamotrigine is correct?
- A. Is the first choice for absence seizures.
- B. Has a half-life of approximately 24 hours. (Correct Answer)
- C. Is not significantly metabolized in the liver.
- D. Has decreased efficacy in treating depressive episodes.
Explanation: ***Has a half-life of approximately 24 hours.*** - Lamotrigine's **half-life** is typically around **24 to 33 hours** in adults, which allows for once or twice-daily dosing. - This relatively long half-life is advantageous for maintaining **stable plasma concentrations** and improving patient adherence. *Is the first choice for absence seizures.* - **Ethosuximide** or **valproate** are generally considered first-line treatments for **absence seizures**. - Lamotrigine is not the preferred initial therapy due to its **slower titration** and occasional lack of efficacy in this seizure type. *Is not significantly metabolized in the liver.* - Lamotrigine is **significantly metabolized** in the liver, primarily through **glucuronidation** by the **UGT1A4 enzyme**. - This hepatic metabolism explains many of its **drug interactions**, particularly with other antiepileptic drugs affecting UGT enzymes. *Has decreased efficacy in treating depressive episodes.* - Lamotrigine is known for its **mood-stabilizing properties** and is effective in treating and preventing **depressive episodes**, particularly in **bipolar disorder**. - Its efficacy in depression is a key distinguishing feature, making it a valuable option for patients with comorbid mood disorders.
Question 554: Visual field monitoring is important before starting which of the following drugs for epilepsy treatment?
- A. Vigabatrin (Correct Answer)
- B. Topiramate
- C. Valproic acid
- D. Carbamazepine
Explanation: ***Vigabatrin*** - **Vigabatrin** is known to cause **irreversible concentric visual field constriction** (peripheral vision loss) due to retinal toxicity. - Regular **ophthalmological monitoring**, including **visual field testing**, is crucial before and during treatment to detect and manage this adverse effect early. *Topiramate* - Topiramate can cause **acute angle-closure glaucoma** and **myopia**, which affect vision, but regular visual field monitoring is not a primary requirement for this specific side effect. - Its main concerns often relate to cognitive side effects and kidney stones, rather than progressive visual field loss requiring baseline and ongoing field testing. *Valproic acid* - Valproic acid is not typically associated with specific visual field defects requiring routine monitoring. - Its major side effects often involve **hepatotoxicity**, **pancreatitis**, and **teratogenicity**. *Carbamazepine* - Carbamazepine's notable side effects include **aplastic anemia**, **hyponatremia**, and **Stevens-Johnson syndrome**. - While it can cause some ocular side effects like **diplopia** or **nystagmus**, it does not typically lead to the progressive and irreversible visual field constriction seen with vigabatrin, which necessitates strict monitoring.
Psychiatry
1 questionsWhich of the following is an antipsychotic drug?
NEET-PG 2013 - Psychiatry NEET-PG Practice Questions and MCQs
Question 551: Which of the following is an antipsychotic drug?
- A. Flupenthixol (Correct Answer)
- B. Rasagiline
- C. Clobazam
- D. Divalproex
Explanation: ***Flupenthixol*** - **Flupenthixol** is a **first-generation (typical) antipsychotic** used primarily for managing **schizophrenia** and other psychotic disorders. - It acts by blocking **dopamine D2 receptors** in the brain, reducing positive symptoms like **hallucinations and delusions**. *Rasagiline* - **Rasagiline** is a **monoamine oxidase-B (MAO-B) inhibitor** used in the treatment of **Parkinson's disease**. - It works by preventing the breakdown of **dopamine** in the brain, thereby improving motor symptoms, and is not an antipsychotic. *Clobazam* - **Clobazam** is a **benzodiazepine** primarily indicated for the treatment of **epilepsy** (specifically Lennox-Gastaut syndrome) and **anxiety**. - Its mechanism involves enhancing the effect of **GABA** in the brain, producing sedative and anticonvulsant effects, distinct from antipsychotic action. *Divalproex* - **Divalproex** is a combination product of **valproic acid** and **sodium valproate**, typically used as a **mood stabilizer** for **bipolar disorder**, an **antiepileptic**, and for **migraine prophylaxis**. - It modulates **GABAergic** transmission and sodium channels, but it is not classified as an antipsychotic drug.
Surgery
2 questionsIn blast injury, which organ is most likely to be damaged first?
What is the term used for choking of the respiratory passage by a bolus of food?
NEET-PG 2013 - Surgery NEET-PG Practice Questions and MCQs
Question 551: In blast injury, which organ is most likely to be damaged first?
- A. Tympanic membrane (Correct Answer)
- B. Liver
- C. Lung
- D. Gastrointestinal tract
Explanation: ***Tympanic membrane*** - The **tympanic membrane** is the most sensitive organ to the pressure waves generated by a blast, often rupturing even with relatively low blast overpressures. - Its thin, delicate structure and direct exposure to external air pressure make it highly vulnerable to barotrauma. *Gastrointestinal tract* - While the **gastrointestinal tract** can be damaged by blast waves, especially air-filled organs, this typically occurs after the tympanic membrane is affected. - Damage often includes hemorrhage, perforation, and mesenteric injury. *Liver* - The **liver** is a solid organ and is less susceptible to initial blast injury compared to air-filled structures. - Damage to the liver usually results from secondary mechanisms like blunt trauma from displacement or impact against other structures. *Lung* - **Blast lung** is a serious injury characterized by pulmonary contusions, hemorrhage, and edema, but it generally requires higher blast overpressure than tympanic membrane rupture. - The air-filled nature of the lungs makes them susceptible, but the tympanic membrane almost always fails first.
Question 552: What is the term used for choking of the respiratory passage by a bolus of food?
- A. Gagging
- B. Choking due to obstruction
- C. Cafe Coronary (Correct Answer)
- D. Suffocation due to food
Explanation: ***Cafe Coronary*** - This term describes sudden death caused by **obstruction of the airway by food**, often mistaken for a heart attack due to the sudden collapse. - It specifically refers to choking on food that leads to **asphyxiation**, frequently occurring in public eating places. *Gagging* - **Gagging** is a protective reflex that prevents objects from entering the throat or causing choking, but it doesn't describe the choking event itself. - It usually involves involuntary contractions of the pharynx and soft palate, often leading to **retching**. *Choking due to obstruction* - This is a general term for **airway obstruction** by anything, while "cafe coronary" specifically refers to food. - While accurate, it lacks the specific medical terminology used to describe food-induced fatal choking. *Suffocation due to food* - **Suffocation** is a broader term for oxygen deprivation, which can be caused by various means, not exclusively food. - While food can lead to suffocation, the term **"cafe coronary"** is more precise for the scenario of sudden death from food lodged in the respiratory passage.