NEET-PG 2013 Practice Questions

Q: Which muscle will be paralyzed when the radial nerve is injured just below the spiral groove?

Extensor Carpi Radialis Brevis. Extensor Carpi Radialis Brevis - The radial nerve travels in the spiral groove of the humerus and gives off branches in a specific sequence. - Proximal to the spiral groove: Branches to triceps and anconeus - Within/at the spiral groove: Branches to brachioradialis and extensor carpi radialis longus (ECRL) - Just distal to the spiral groove: Branch to extensor carpi radialis brevis (ECRB) [1] - this is the first branch after exiting the spiral groove - More distally: The nerve divides into superficial and deep branches (posterior interosseous nerve) [1] - An injury just below the spiral groove would paralyze ECRB while sparing muscles innervated proximal to or within the groove (triceps, anconeus, brachioradialis, ECRL). Supinator - The supinator is innervated by the deep branch of the radial nerve (posterior interosseous nerve), which branches off more distally in the proximal forearm. - This muscle would only be affected by injuries distal to the bifurcation of the radial nerve into superficial and deep branches, not by an injury just below the spiral groove. Extensor Digitorum - The extensor digitorum is supplied by the posterior interosseous nerve, which is a continuation of the deep branch [1]. - This innervation occurs significantly distal to the spiral groove in the posterior forearm compartment. - It would be affected by posterior interosseous nerve injuries, not by lesions just below the spiral groove. Abductor Pollicis Longus - The abductor pollicis longus is innervated by the posterior interosseous nerve in the distal forearm [1]. - This is the most distal of all the options and would only be affected by posterior interosseous nerve palsy, not by radial nerve injury at the spiral groove level [1].

Q: Which muscle receives a muscular branch from the ulnar nerve?

Both FCU and FDP. ***Both FCU and FDP*** - The **flexor carpi ulnaris (FCU)** is solely innervated by the **ulnar nerve** in the forearm. - The **flexor digitorum profundus (FDP)** has dual innervation: the **ulnar nerve** supplies the medial half (tendons to ring and little fingers), while the anterior interosseous nerve (branch of median nerve) supplies the lateral half (tendons to index and middle fingers). - Both muscles receive muscular branches from the ulnar nerve, making this the most complete and accurate answer. *FCU* - While the FCU does receive innervation from the ulnar nerve (and only the ulnar nerve), this option is incorrect because the FDP also receives branches from the ulnar nerve. - Selecting only FCU ignores the dual innervation of FDP and is therefore an incomplete answer when "Both FCU and FDP" is available. *FDP* - While the medial half of FDP does receive innervation from the ulnar nerve, this option is incorrect because FCU also receives innervation from the ulnar nerve. - Selecting only FDP ignores the complete innervation of FCU and is therefore an incomplete answer when "Both FCU and FDP" is available. *None of the options* - This option is incorrect because both the **flexor carpi ulnaris** and the medial portion of the **flexor digitorum profundus** definitively receive muscular branches from the ulnar nerve. - The ulnar nerve provides motor innervation to these specific forearm muscles before continuing into the hand.

Q: All of the following muscles have dual nerve supply except which one?

Biceps brachii. ***Biceps brachii*** - The **biceps brachii** muscle is solely innervated by the **musculocutaneous nerve (C5, C6, C7)**. - This muscle is a prime mover for forearm supination and elbow flexion and does not receive nerve supply from any other nerve. *Subscapularis* - The **subscapularis** muscle has a dual nerve supply from both the **upper and lower subscapular nerves (C5, C6)**. - This dual innervation ensures motor control of the subscapularis, which is an important medial rotator of the humerus. *Pectoralis major* - The **pectoralis major** muscle receives a dual nerve supply from both the **medial and lateral pectoral nerves** [1]. - The **lateral pectoral nerve** primarily supplies the clavicular head, while the **medial pectoral nerve** supplies both the sternocostal head and a portion of the clavicular head [1]. *Flexor digitorum profundus* - The **flexor digitorum profundus** muscle has a dual nerve supply from the **median nerve** (innervating the lateral half for digits 2 and 3) and the **ulnar nerve** (innervating the medial half for digits 4 and 5). - This dual innervation allows for independent or coordinated flexion of the distal phalanges of the fingers.

Q: Which muscle is not part of the superficial anterior compartment of the forearm?

Flexor pollicis longus (FPL). **Flexor pollicis longus (FPL)** - The **FPL** is located in the **deep anterior compartment** of the forearm, differentiating it from the superficial muscles [1]. - Its primary function is **flexion of the thumb's interphalangeal joint**, requiring a deeper anatomical position for mechanical advantage [1]. *FDS* - The **Flexor digitorum superficialis (FDS)** is a key muscle of the superficial anterior compartment, visible just beneath the skin and fascia. - It is responsible for **flexing the middle phalanges** of the medial four digits. *FCR* - The **Flexor carpi radialis (FCR)** is situated in the superficial anterior compartment, running obliquely across the forearm. - It functions in **flexion and abduction of the wrist**. *Palmaris longus* - The **Palmaris longus** is a superficial anterior compartment muscle, though it is absent in a significant portion of the population. - When present, its main action is **flexion of the wrist** and tightening of the palmar aponeurosis.

Q: What is the nerve supply to the muscles of the flexor compartment of the arm?

Musculocutaneous nerve. ***Musculocutaneous nerve*** - The **musculocutaneous nerve** is the primary nerve supplying all three muscles in the **flexor compartment of the arm**: the **biceps brachii**, **brachialis**, and **coracobrachialis**. - Its motor branches innervate these muscles, allowing for **flexion at the elbow** and **supination of the forearm**. *Median nerve* - The **median nerve** primarily innervates most muscles in the **flexor compartment of the forearm**, not the arm. - It plays a crucial role in **wrist and finger flexion**, as well as movements of the **thenar eminence**. *Radial nerve* - The **radial nerve** is the main nerve for the **extensor compartment of the arm and forearm**. - It is responsible for **elbow, wrist, and finger extension**. *Ulnar nerve* - The **ulnar nerve** primarily supplies intrinsic muscles of the hand and some flexor muscles in the forearm. - It has no motor supply to the muscles of the **flexor compartment of the arm**.

Q: Which is the primary muscle causing supination of the forearm?

Supinator. ***Supinator*** - The **supinator muscle** is the **primary muscle** responsible for **supination** of the forearm, rotating the palm anteriorly or superiorly. - It is a deep muscle of the **posterior compartment** of the forearm. - Its action is especially prominent when **supinating against resistance** or in very slow movements, as it works synergistically with the biceps brachii. *Biceps brachii* - While the **biceps brachii** is also a powerful **supinator** of the forearm, especially when the elbow is flexed, it is a **secondary supinator**. - It is primarily a major **flexor** of the elbow, whereas the supinator is dedicated specifically to supination. *Brachioradialis* - The **brachioradialis** is primarily a **flexor** of the forearm at the elbow joint. - It helps to bring the forearm into a **mid-prone or mid-supine position** from either full pronation or full supination, but does not actively supinate. *Anconeus* - The **anconeus** is a small muscle that assists the **triceps brachii** in **extension of the forearm** at the elbow. - It helps to **stabilize the elbow joint** and slightly abducts the ulna during pronation, but has no role in supination.

Q: Which one of the following is the most common CNS tumor associated with type I neurofibromatosis?

Optic nerve glioma. ***Optic nerve glioma*** - **Optic nerve gliomas** are the most frequently encountered central nervous system tumors in patients with **Type 1 neurofibromatosis (NF1)**, occurring in about 15% of individuals. - They are typically low-grade **astrocytomas** and can cause vision loss and proptosis depending on their size and location. *Meningioma* - While more common in **Type 2 neurofibromatosis (NF2)**, meningiomas can occur in NF1, but are not the most common CNS tumor. - Meningiomas are tumors that arise from the **meninges**, the membranes surrounding the brain and spinal cord. *Acoustic schwannoma* - **Bilateral acoustic schwannomas (vestibular schwannomas)** are the hallmark feature of **Type 2 neurofibromatosis (NF2)**, not NF1 [1]. - These tumors arise from the Schwann cells of the **vestibulocochlear nerve** and can cause hearing loss and balance issues [1]. *Low grade astrocytoma* - While optic nerve gliomas are a type of low-grade astrocytoma, this option is too general; **optic nerve glioma** is the specific and most common presentation in NF1. - Other forms of low-grade astrocytomas can occur in NF1 but are not as universally characteristic as optic nerve gliomas.

Q: Linitis plastica is a type of ?

Manifestation of gastric cancer. ***Diffuse carcinoma of stomach*** - Linitis plastica is a specific type of **gastric cancer** characterized by **thickening of the stomach wall**, leading to a rigid, non-distensible abdomen [1]. - It often presents with **significant weight loss** and **early satiety**, distinguishing it from other stomach conditions. *Benign ulcer* - Benign ulcers do not cause the **extensive wall thickening** or **desmoplastic response** seen in linitis plastica [1]. - They typically heal with treatment and are associated with typical ulcer symptoms, unlike the progressive nature of linitis plastica. *Plastic like lining of stomach* - While linitis plastica describes a **plastic-like appearance**, it is not classified as a mere lining change but rather a sign of underlying **malignancy** [1]. - This option misrepresents it as a benign condition rather than a serious **stomach adenocarcinoma**. *GIST* - Gastrointestinal stromal tumors (GIST) are **soft tissue tumors** of mesenchymal origin, differing fundamentally from the **invasive** characteristics of linitis plastica [2]. - GISTs typically present with **mass lesions** in the GI tract, not the diffuse rigidity seen in linitis plastica [1]. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Gastrointestinal Tract, pp. 779-780. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Gastrointestinal Tract, p. 779.

Q: Gastric carcinoma is associated with all of the following EXCEPT:

Activation of RAS. ***Activation of RAS*** - **RAS mutations** are relatively uncommon in gastric carcinoma compared to other gastrointestinal malignancies. While KRAS mutations can occur in approximately 10-15% of gastric cancers (particularly intestinal type), they are **far less frequent** than in **pancreatic adenocarcinoma** (~90%) or **colorectal carcinoma** (~40%). - In the context of gastric carcinoma, RAS pathway alterations are **not considered a major oncogenic driver** compared to the other molecular changes listed, making this the **LEAST characteristically associated** alteration. *Inactivation of p53* - **Inactivation of the p53 tumor suppressor gene** is one of the most frequent molecular events in gastric carcinoma, occurring in approximately **50-60% of cases**. - Loss of p53 function leads to genomic instability, uncontrolled cell proliferation, and resistance to apoptosis, contributing significantly to **tumorigenesis** and **poor prognosis**. *Over expression of C-met* - **Overexpression of C-MET**, a receptor tyrosine kinase for hepatocyte growth factor (HGF), is commonly observed in gastric carcinoma (30-40% of cases) and is strongly linked to **tumor growth**, **invasion**, and **metastasis**. - C-MET amplification and overexpression promote cell proliferation, survival, migration, and angiogenesis, making it an important **therapeutic target** in advanced gastric cancer. *Over expression of C-erb* - **Overexpression of C-erbB-2 (HER2/neu)** is found in approximately **10-20% of gastric adenocarcinomas**, particularly the intestinal type. - HER2 amplification or overexpression is a significant **prognostic and predictive biomarker**, and is specifically targeted by **trastuzumab** (Herceptin) therapy in HER2-positive advanced gastric cancer, improving survival outcomes.

Q: Donath-Landsteiner antibody is seen in?

Paroxysmal cold hemoglobinuria. ***Paroxysmal cold hemoglobinuria*** - **Donath-Landsteiner antibody** is a **biphasic IgG autoantibody** that binds to red blood cells in the cold and causes **hemolysis** upon warming, characteristic of paroxysmal cold hemoglobinuria. - This antibody has **anti-P specificity**, meaning it targets the P antigen on red blood cells, leading to complement activation and cell lysis. *PNH* - **Paroxysmal nocturnal hemoglobinuria** (PNH) is characterized by a deficiency in **GPI-anchored proteins** on red blood cells, notably **CD55** and **CD59**, making them susceptible to complement-mediated lysis. - It is not associated with the Donath-Landsteiner antibody; rather, it is identified by **flow cytometry** showing absence of CD55/CD59. *Waldenstrom's macroglobulinemia* - This is a **B-cell lymphoma** characterized by the overproduction of **monoclonal IgM antibodies**, leading to hyperviscosity syndrome and other symptoms. - It does not involve Donath-Landsteiner antibodies or cold-induced hemolysis in the same manner as paroxysmal cold hemoglobinuria. *Malaria* - **Malaria** is caused by **Plasmodium parasites** that infect and destroy red blood cells, leading to hemolytic anemia and fever. - While it causes **hemolysis**, it is not mediated by the Donath-Landsteiner antibody; the destruction is primarily due to parasitic replication and immune responses against infected cells.

Question 1

Which muscle will be paralyzed when the radial nerve is injured just below the spiral groove?

Accepted Answer

Extensor Carpi Radialis Brevis

Answer

Extensor Digitorum

Answer

Supinator

Answer

Abductor Pollicis Longus

Question 2

Which muscle receives a muscular branch from the ulnar nerve?

Accepted Answer

Both FCU and FDP

Answer

FCU

Answer

None of the options

Answer

FDP

Question 3

All of the following muscles have dual nerve supply except which one?

Accepted Answer

Biceps brachii

Answer

Pectoralis major

Answer

Flexor digitorum profundus

Answer

Subscapularis

Question 4

Which muscle is not part of the superficial anterior compartment of the forearm?

Accepted Answer

Flexor pollicis longus (FPL)

Answer

FDS

Answer

FCR

Answer

Palmaris longus

Question 5

What is the nerve supply to the muscles of the flexor compartment of the arm?

Accepted Answer

Musculocutaneous nerve

Answer

Median nerve

Answer

Radial nerve

Answer

Ulnar nerve

Question 6

Which is the primary muscle causing supination of the forearm?

Accepted Answer

Supinator

Answer

Brachioradialis

Answer

Anconeus

Answer

Biceps brachii

Question 7

Which one of the following is the most common CNS tumor associated with type I neurofibromatosis?

Accepted Answer

Optic nerve glioma

Answer

Meningioma

Answer

Acoustic schwannoma

Answer

Low grade astrocytoma

Question 8

Linitis plastica is a type of ?

Accepted Answer

Manifestation of gastric cancer

Answer

Benign ulcer

Answer

GIST

Answer

Plastic-like appearance of stomach lining

Question 9

Gastric carcinoma is associated with all of the following EXCEPT:

Accepted Answer

Activation of RAS

Answer

Over expression of C-met

Answer

Inactivation of p53

Answer

Over expression of C-erb

Question 10

Donath-Landsteiner antibody is seen in?

Accepted Answer

Paroxysmal cold hemoglobinuria

Answer

PNH

Answer

Waldenstrom's macroglobulinemia

Answer

Malaria

NEET-PG 2013

Anatomy

Internal Medicine

Pathology