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INI-CET 2018 — General Medicine

Q: Which disease occurs due to involvement of the structure marked in red? (AIIMS May 2018)

Paralysis agitans. ***Paralysis agitans*** - The red circle points to the **substantia nigra**, a key brain structure involved in producing **dopamine**. - **Paralysis agitans**, also known as **Parkinson's disease**, is characterized by the degeneration of dopaminergic neurons in the substantia nigra, leading to motor symptoms like tremor, rigidity, and bradykinesia. *Depression* - Depression is a mood disorder associated with imbalances in various **neurotransmitters** (e.g., serotonin, norepinephrine, dopamine) and often involves brain regions such as the prefrontal cortex and limbic system, not primarily the substantia nigra. - While dopamine pathways can be implicated in motivation and reward, the primary pathology of major depression is not direct degeneration of the substantia nigra. *Alzheimer's disease* - Alzheimer's disease is a neurodegenerative disorder primarily characterized by the accumulation of **amyloid plaques** and **neurofibrillary tangles**, leading to neuronal loss and brain atrophy, particularly in the hippocampus and cerebral cortex, not the substantia nigra. - It results in progressive **memory loss** and cognitive decline, distinct from the motor symptoms seen in Parkinson's. *Huntington's chorea* - Huntington's chorea is a hereditary neurodegenerative disease caused by the degeneration of GABAergic neurons in the **striatum** (caudate and putamen). - It is characterized by **involuntary movements** (chorea), cognitive decline, and psychiatric symptoms, which result from basal ganglia dysfunction but not specifically originating from the substantia nigra. [Practice more General Medicine PYQs on OnCourse]

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All Subjects Anatomy (1)Anatomy (21)Community Medicine (4)Dermatology (5)Forensic Medicine (7)General Medicine (1)Microbiology (2)Ophthalmology (3)Orthopaedics (6)Pathology (2)Pathology (2)Physiology (3)Radiology (5)Surgery (2)Surgery (4)

Which disease occurs due to involvement of the structure marked in red? (AIIMS May 2018)