Drug interactions and adverse effects — Flashcards

Flashcard 1: thalidomide

Answer: limb defects (flipper limbs)

Flashcard 2: warfarin

Answer: bone deformities, fetal hemmorhage, abortion, ophthalmologic abnormalities

Flashcard 3: disulfiram

Answer:

Extra: quitting alcohol useinhibits acetylaldehyde dehydrogenasewicked hangover-like symptoms (which are actually the desired effect)

Flashcard 4: Which vitamins, water or fat soluble, are more likely to cause toxicity? Why?

Answer: fat soluble; sequester in fat, less easy to wash out

Flashcard 5: Phase IV

Answer: Patients using the drug in the general population (required post-marketing surveillance)

Extra: Rare or long-term effects