Serotonin syndrome — Flashcards

Flashcard 1: First Aid Pharmacology: Neuro/Psych MAO inhibitors may cause CNS _____ (stimulation or depression)

Answer: stimulation

Flashcard 2: Adverse effects of clonidine include CNS and respiratory _____

Answer: depression

Flashcard 3: What treatment for headaches is associated with serotonin syndrome? _____

Answer: Triptans

Flashcard 4: Which antibiotic can precipitate serotonin toxicity when coadministered with SSRIs, SNRIs, MAOIs, and bupropion?

Answer: Linezolid

Flashcard 5: Ondansetron may cause _____, which presents with symptoms including rigidity, tremor, hyperthermia, and confusion

Answer: serotonin syndrome

Flashcard 6: Which serotonin receptor is inhibited by trazodone? _____

Answer: 5-HT2

Flashcard 7: What antibiotic can increase risk for serotonin syndrome? _____

Answer: Linezolid

Flashcard 8: thalidomide

Answer: limb defects (flipper limbs)

Flashcard 9: What are the teratogenic effects of warfarin?

Answer: Bone deformities (stippled epiphyses, nasal hypoplasia), fetal hemorrhage, abortion, ophthalmologic abnormalities

Extra: Warfarin inhibits epoxide reductase, interfering with γ-carboxylation of glutamate residues (including Osteocalcin). Exposure during 6-9 weeks gestation leads to Fetal Warfarin Syndrome.

Flashcard 10: Mechanism of action of Disulfiram?

Answer: Inhibits aldehyde dehydrogenase (ALDH)

Extra: Mechanism: Inhibits aldehyde dehydrogenase → accumulation of acetaldehyde → Disulfiram-like reaction (wicked hangover-like symptoms: flushing, tachycardia, nausea/vomiting, hypotension). Used as an alcohol deterrent (aversion therapy).