Drug-induced liver injury — Flashcards

Flashcard 1: Rifampin use is associated with _____-toxicity

Answer: hepato

Flashcard 2: What adverse effect is associated with bosentan? _____

Answer: Hepatotoxicity (thus monitor LFTs)

Flashcard 3: _____ toxicity is associated with Isoniazid use

Answer: Hepato

Flashcard 4: Acetaminophen toxicity results in depletion of hepatic _____ stores by NAPQI

Answer: glutathione

Flashcard 5: N-acetylcysteine helps restore _____ stores in the setting of acetaminophen toxicity

Answer: reduced glutathione

Flashcard 6: Tolcapone can cause _____ failure as an adverse effect

Answer: hepatic

Flashcard 7: What adverse effect is associated with zileuton?_____

Answer: Hepatotoxicity

Flashcard 8: thalidomide

Answer: limb defects (flipper limbs)

Flashcard 9: What are the teratogenic effects of warfarin?

Answer: Bone deformities (stippled epiphyses, nasal hypoplasia), fetal hemorrhage, abortion, ophthalmologic abnormalities

Extra: Warfarin inhibits epoxide reductase, interfering with γ-carboxylation of glutamate residues (including Osteocalcin). Exposure during 6-9 weeks gestation leads to Fetal Warfarin Syndrome.

Flashcard 10: Mechanism of action of Disulfiram?

Answer: Inhibits aldehyde dehydrogenase (ALDH)

Extra: Mechanism: Inhibits aldehyde dehydrogenase → accumulation of acetaldehyde → Disulfiram-like reaction (wicked hangover-like symptoms: flushing, tachycardia, nausea/vomiting, hypotension). Used as an alcohol deterrent (aversion therapy).