Antivirals — Flashcards

Flashcard 261: Which class of HAART drugs compete with nucleotides for binding to HIV reverse transcriptase?_____

Answer: NRTIs

Flashcard 262: Gardasil HPV vaccine is what type of vaccine? _____

Answer: Recombinant subunit

Flashcard 263: Which NRTI is associated with anemia and granulocytopenia?_____

Answer: Zidovudine

Flashcard 264: Which NRTI is associated with dose-dependent pancreatitis?_____

Answer: Didanosine

Flashcard 265: Treatment for CMV includes _____, Valganciclovir or Foscarnet/cidofovir

Answer: Ganciclovir

Flashcard 266: Which type of HAART drug is Fosamprenavir?_____

Answer: Protease inhibitor

Flashcard 267: Which NRTI is a nucleo**tide** and thus bypasses the **initial** phosphorylation step?

Answer: Tenofovir

Extra: Most NRTIs are nucleo**s**ides and require three phosphorylation steps (by host cell kinases) to become active. Tenofovir is a nucleo**tide** (nucleoside monophosphate analog) and thus bypasses the initial phosphorylation step.

Flashcard 268: Which HIV protease inhibitor can result in nephrolithiasis?_____

Answer: Indinavir

Flashcard 269: Which type of HAART drug is Maraviroc?

Answer: Entry inhibitor (CCR5 antagonist)

Flashcard 270: Which HAART drug class commonly causes lipodystrophy?_____

Answer: Protease inhibitors