HIV reverse transcriptase inhibitors — Flashcards

Flashcard 1: Non-nucleoside RTIs (NNRTIs) directly inhibit _____ by binding to a different site from NRTIs

Answer: HIV reverse transcriptase

Flashcard 2: NNRTIs have varying effects on _____ and thus may have many drug interactions

Answer: CYP450

Flashcard 3: Which class of HAART drugs inhibit HIV mRNA formation?_____

Answer: Integrase inhibitors

Flashcard 4: Resistance to Cidofovir and Foscarnet occurs with mutations to _____

Answer: viral DNA polymerase

Flashcard 5: Which NRTI is associated with a hypersensitivity reaction in patients with the HLA-B 57:01 allele?_____

Answer: Abacavir

Flashcard 6: Which class of HAART drugs compete with nucleotides for binding to HIV reverse transcriptase?_____

Answer: NRTIs

Flashcard 7: Which type of HAART drug is abacavir (ABC)?_____

Answer: NRTI

Flashcard 8: The backbone of Highly active antiretroviral therapy (HAART) are _____ such as Zidovudine

Answer: NRTIs

Flashcard 9: NNRTIs are associated with _____, that can manifest as a more severe pathology such as Stevens-Johnson syndrome

Answer: rash

Flashcard 10: Clinical uses and key side effects of Amantadine

Answer: Uses: Influenza A, Parkinson's disease\nSide effects: Livedo reticularis, ataxia

Extra: Mechanism: Blocks M2 ion channel (Influenza A); increases dopamine release. \u001fNote: Amantadine is also used to treat rubella-associated arthritis in some contexts, though its primary associations are Influenza A and PD. \u001fCommon side effect: Livedo reticularis.