Antivirals — Flashcards

Flashcard 251: Do NNRTIs compete with nucleotides for binding to reverse transcriptase?_____

Answer: No

Flashcard 252: Do NRTIs require phosphorylation to be activated?_____

Answer: Yes

Flashcard 253: What type of vaccine is the preferred Zoster vaccine (Shingrix)?

Answer: Recombinant subunit vaccine

Extra: Shingrix (Recombinant Zoster Vaccine) is the preferred vaccine for the prevention of herpes zoster (shingles). The Varicella (chickenpox) vaccine and the older Zoster vaccine (Zostavax) are live-attenuated vaccines. Shingrix is preferred due to higher efficacy and its non-live nature.

Flashcard 254: Which influenza vaccine can result in CD8+ T-cell response?_____

Answer: Live, intranasal vaccine

Flashcard 255: NRTIs lack a 3 hydroxyl group, causing strand termination when binding to _____

Answer: HIV reverse transcriptase

Flashcard 256: Interferon Beta protects the _____ Barrier by preventing extravasation of lymphocytes

Answer: Blood Brain

Flashcard 257: Which NRTI is associated with dose-dependent pancreatitis?_____

Answer: Didanosine

Flashcard 258: Which type of HAART drug is Fosamprenavir?_____

Answer: Protease inhibitor

Flashcard 259: Foscarnet can cause _____ due to electrolyte disturbances

Answer: seizures

Flashcard 260: Treatment for CMV includes _____, Valganciclovir or Foscarnet/cidofovir

Answer: Ganciclovir