Antivirals — Flashcards

Flashcard 241: The treatment guideline for HIV is: 2 _____ and either: _____ _____ _____

Answer: NRTIs

Extra:  https://onlinemeded.org/spa/infectious-disease/hiv/acquire?ref=anki 

Flashcard 242: postexposure HIV prophylaxis = _____

Answer: 3 drug (2+1) for 4 weeks

Extra: Reference: https://onlinemeded.org/spa/infectious-disease/hiv/acquire

Flashcard 243: Postexposure prophylaxis of rabies includes administration of _____ and rabies immunoglobulin (passive immunization)

Answer: killed rabies vaccine (active immunization)

Extra:  https://onlinemeded.org?ref=anki 

Flashcard 244: Post-exposure prophylaxis (PEP) for Rabies\n_____

Answer: (1) Rabies immune globulin (passive immunization)\n(2) Inactivated vaccine (active immunization)\n(PEP is effective due to time lag between infecting motor end plate and replicating in motor neurons)

Extra: Rabies post-exposure prophylaxis (PEP) is effective because the virus travels slowly via retrograde axonal transport from the site of the bite to the central nervous system. PEP consists of thorough wound cleansing, rabies immune globulin (RIG) for passive immunity, and an inactivated rabies vaccine series for active immunity.

Flashcard 245: Yellow fever vaccine is contraindicated in those with a(n) _____ allergy

Answer: egg

Extra:  https://onlinemeded.org/spa/pediatrics/vaccinations/acquire?ref=anki 

Flashcard 246: The quadrivalent vaccine Gardasil protects against HPV types _____

Answer: 6,11,16,18

Extra:  https://onlinemeded.org/spa/gynecology/cervical-cancer/acquire?ref=anki 

Flashcard 247: Which NRTI is associated with myelosuppresion?_____

Answer: Zidovudine

Flashcard 248: What type of vaccine is the preferred Zoster vaccine (Shingrix)?

Answer: Recombinant subunit vaccine

Extra: Shingrix (Recombinant Zoster Vaccine) is the preferred vaccine for the prevention of herpes zoster (shingles). The Varicella (chickenpox) vaccine and the older Zoster vaccine (Zostavax) are live-attenuated vaccines. Shingrix is preferred due to higher efficacy and its non-live nature.

Flashcard 249: Do NNRTIs compete with nucleotides for binding to reverse transcriptase?_____

Answer: No

Flashcard 250: Do NRTIs require phosphorylation to be activated?_____

Answer: Yes