Antivirals — Flashcards

Flashcard 121: What drug is contraindicated in children with viral illness? _____

Answer: Aspirin

Flashcard 122: Which NNRTI is contraindicated in pregnancy? _____

Answer: Delavirdine

Extra: Delavirdine is contraindicated in pregnancy. Note: **Efavirenz** was previously considered contraindicated due to a perceived risk of neural tube defects (NTDs), but modern guidelines (WHO/DHHS) now consider it safe for use in pregnancy and it is often part of first-line regimens globally.

Flashcard 123: Which strain(s) of influenza are treated with M2 channel blockers (rimantidine, amantadine)? _____

Answer: Influenza A

Flashcard 124: Which two anti-influenza drugs inhibit neuraminidase (NA)? _____

Answer: Zanamivir; Oseltamivir

Extra: Oseltamivir and Zanamivir inhibit influenza neuraminidase, decreasing the release of progeny virus.

Flashcard 125: In their first step of bioactivation, -cyclovirs are converted to the _____ form by specific herpesvirus kinases

Answer: monophosphate

Flashcard 126: Which type of HAART drug is emtricitabine (FTC)? _____

Answer: NRTI

Flashcard 127: What classes of HAART drugs directly inhibit HIV reverse transcriptase? _____

Answer: NRTIs; NNRTIs

Extra: HAART: Highly Active Antiretroviral Therapy.

Flashcard 128: Which type of HAART drug is abacavir (ABC)? _____

Answer: NRTI

Flashcard 129: Which antiviral is used during solid-organ and bone marrow transplant? _____

Answer: Ganciclovir or Valganciclovir

Flashcard 130: Simeprevir is a(n) inhibitor of _____ and thus may have many drug interactions

Answer: cytochrome P450