Antivirals — Flashcards

Flashcard 111: Palivizumab is a monoclonal antibody against the _____ of RSV

Answer: fusion (F) protein

Flashcard 112: Acyclovir, famciclovir, and valacyclovir are used to treat _____ VZV and HSV infections

Answer: active

Flashcard 113: Foscarnet is a(n) _____ analog

Answer: Pyrophosphate

Flashcard 114: Drugs like Dolutegravir, Elvitegravir, and Raltegravir reversibly inhibit _____

Answer: HIV integrase

Flashcard 115: Once -cyclovir's are bioactivated to their triphosphate form, these then inhibit viral DNA polymerase by _____ nascent DNA strand

Answer: incorporation into the

Flashcard 116: NRTIs are associated with _____ toxicity and lactic acidosis

Answer: mitochondrial

Flashcard 117: Which type of HAART drug is didanosine (ddl)? _____

Answer: NRTI

Flashcard 118: Acyclovir triphosphate incorporates into replicating viral DNA, inhibiting _____

Answer: DNA-dependent DNA polymerase

Flashcard 119: Simeprevir is a NS3/4A _____ inhibitor that may be used for the treatment of hepatitis C genotype 1

Answer: protease

Extra: Sketchy Pharmacology: GI (Hepatitis)

Flashcard 120: Will a short (7-10 day) course of treatment with acyclovir during the primary genital HSV infection alter recurrence rates? _____

Answer: No