Antivirals — Flashcards

Flashcard 131: Simeprevir is a(n) inhibitor of _____ and thus may have many drug interactions

Answer: cytochrome P450

Flashcard 132: Do NNRTIs compete with nucleotides for binding to reverse transcriptase? _____

Answer: No

Flashcard 133: Ganciclovir and Valganciclovir are used to treat CMV, especially in _____ patients

Answer: immunocompromised

Flashcard 134: Uncommon side-effects of acyclovir include _____, confusion, vertigo, and _____

Answer: delirium

Flashcard 135: Simeprevir can cause drug-drug interactions by inhibiting _____

Answer: cytochrome p450

Flashcard 136: If a patient taking Integrase Inhibitors can develops elevated Creatine Kinase levels, what should you suspect is occurring? _____

Answer: Rhabdomyolysis

Flashcard 137: Enfuvirtide prevents HIV infection by binding what HIV glycoprotein? _____

Answer: gp41

Flashcard 138: Which NRTI is associated with myelosuppression? _____

Answer: Zidovudine

Flashcard 139: _____ can be used to treat urogenital warts by activating TLR-7, leading to unregulated pro-inflammatory transcription factor NF-kB which initiates the immune response

Answer: Imiquimod

Flashcard 140: Do NRTIs need to be phosphorylated by host cellular kinases to be active? _____

Answer: Yes

Extra: Mechanism: Competitive inhibition of HIV reverse transcriptase; causes DNA chain termination (due to lack of a 3' OH group).