Antibiotics — Flashcards

Flashcard 811: What class of drugs does bleomycin belong to?_____

Answer: antitumor antibiotics

Flashcard 812: Polymixins work by binding to _____ on bacterial cell membranes

Answer: LPS

Flashcard 813: Is the recurrence rate of C. difficile colitis lower or higher when taking Fidaxomicin than with vancomycin?_____

Answer: Significantly lower

Flashcard 814: Allopurinol hypersensitivity can result in _____ syndrome, which is characterized by sloughing of the skin

Answer: Stevens-Johnson

Flashcard 815: Aztreonam works by binding to penicillin binding protein _____

Answer: 3 (#)

Flashcard 816: Prophylaxis before dental procedures in patients at high risk for endocarditis_____

Answer: Amoxicillin

Flashcard 817: What is the mechanism of action of **Fluoroquinolones**?

Answer: Inhibition of **DNA gyrase** (topoisomerase II) and **topoisomerase IV**

Extra: Fluoroquinolones are bactericidal and disrupt DNA replication by preventing the relaxation of supercoiled DNA and the separation of concatenated daughter chromosomes.

Flashcard 818: Which aminopenicillin has higher oral bioavailability?

Answer: Amoxicillin

Flashcard 819: The benzathine form of Penicillin G makes it _____-acting

Answer: long (repository form)

Flashcard 820: Treatment for Legionella pneumophila infection includes _____ or levofloxacin/moxifloxacin (fluoroquinolones)

Answer: azithromycin (macrolides)