Antibiotics — Flashcards

Flashcard 731: How does MRSA obtain methicillin resistance? Alters _____

Answer: PBP (penicillin-binding proteins)

Flashcard 732: What gout drug can precipitate the side effects of penicillins?_____

Answer: Probenecid

Flashcard 733: What step of bacterial protein synthesis is inhibited by **Clindamycin**?

Answer: Inhibits **translocation** by binding to the **50S** ribosomal subunit.

Extra: Clindamycin's mechanism is similar to macrolides (e.g., erythromycin). It binds to the 50S subunit, preventing the movement of the ribosome along the mRNA (translocation).

Flashcard 734: Which antibiotic depolarizes bacterial cell membranes via creation of transmembrane channels?_____

Answer: Daptomycin

Flashcard 735: Mupirocin is a topical antibiotic that works by inhibiting _____

Answer: isoleucine t-RNA synthetase

Flashcard 736: Which antibiotic causes the misreading of mRNA and inhibition of translation?_____

Answer: Aminoglycosides

Flashcard 737: Carbapenems treat meningitis and pneumonia caused by _____ pathogens

Answer: gram negative

Flashcard 738: Which anti-microbial class is Aztreonam particularly synergistic with?_____

Answer: Aminoglycosides

Flashcard 739: Ampicillin treats meningitis produced by _____.

Answer: Listeria monocytogenes

Flashcard 740: Rifampin is an _____ of CYP-450

Answer: inducer