Antibiotics — Flashcards

Flashcard 691: What nephrotoxicity is caused by Sulfonamides?_____

Answer: Acute interstitial nephritis

Flashcard 692: What is the treatment for E. coli UTI?_____

Answer: TMP-SMX

Flashcard 693: Which enzyme in the bacterial folate synthesis pathway is inhibited by **Trimethoprim**?

Answer: Dihydrofolate reductase (DHFR)

Extra: Trimethoprim inhibits bacterial dihydrofolate reductase, which prevents the reduction of dihydrofolic acid to tetrahydrofolic acid (THF). Sulfonamides inhibit dihydropteroate synthase, the step immediately preceding this in the folate synthesis pathway.

Flashcard 694: Most Carbapenems are very useful against Pseudomonas aeruginosa, except _____ which has limited coverage

Answer: Ertapenem

Flashcard 695: Treatment for Streptococcus agalactiae (GBS) is _____

Answer: penicillin G (specific)

Flashcard 696: What cephalosporin has a long half-life, making it useful for surgical prophylaxis?_____

Answer: Cefazolin

Flashcard 697: The mnemonic CAMPFIRE can be used to remember the drugs effective against _____

Answer: Pseudomonas aeruginosa

Flashcard 698: _____ is a GI complication of ampicillin usethat results from overgrowth of Clostridium difficile in the GI tract.

Answer: Pseudomembranous colitis

Flashcard 699: Which RIPE drug can cause uric acid crystal formation and ultimately gout?_____

Answer: Pyrazinamide

Flashcard 700: Treatment of Brucellosis includes _____ and streptomycin

Answer: doxycycline