Antibiotics — Flashcards

Flashcard 681: Most Carbapenems are very useful against Pseudomonas aeruginosa, except _____ which has limited coverage

Answer: Ertapenem

Flashcard 682: Drug-induced _____ is an immunologic toxicity of Isoniazid use

Answer: lupus

Flashcard 683: Carbapenems can treat aspiration and _____ pneumonia

Answer: hospital-acquired

Flashcard 684: Treatment for Staph aureus infections (not MRSA): _____

Answer: Nafcillin

Flashcard 685: Isoniazid promotes the excretion of _____, therefore resulting in deficiency and peripheral neuropathy

Answer: pyridoxine (Vitamin B6)

Flashcard 686: Which enzyme in the bacterial folate synthesis pathway is inhibited by **Trimethoprim**?

Answer: Dihydrofolate reductase (DHFR)

Extra: Trimethoprim inhibits bacterial dihydrofolate reductase, which prevents the reduction of dihydrofolic acid to tetrahydrofolic acid (THF). Sulfonamides inhibit dihydropteroate synthase, the step immediately preceding this in the folate synthesis pathway.

Flashcard 687: Pyrazinamide is a pro-drug that is converted into the active form, _____, by the enzyme pyrazinamidase

Answer: pyrazinoic acid

Flashcard 688: What nephrotoxicity is caused by Sulfonamides?_____

Answer: Acute interstitial nephritis

Flashcard 689: Which carbapenem has a decreased risk of seizure?_____

Answer: Meropenem

Flashcard 690: What cutaneous pathology can be treated with tetracyclines?_____

Answer: Acne