Antibiotics — Flashcards

Flashcard 681: Isoniazid promotes the excretion of _____, therefore resulting in deficiency and peripheral neuropathy

Answer: pyridoxine (Vitamin B6)

Flashcard 682: Carbapenems can treat aspiration and _____ pneumonia

Answer: hospital-acquired

Flashcard 683: What nephrotoxicity is caused by Sulfonamides?_____

Answer: Acute interstitial nephritis

Flashcard 684: Which enzyme in the bacterial folate synthesis pathway is inhibited by **Trimethoprim**?

Answer: Dihydrofolate reductase (DHFR)

Extra: Trimethoprim inhibits bacterial dihydrofolate reductase, which prevents the reduction of dihydrofolic acid to tetrahydrofolic acid (THF). Sulfonamides inhibit dihydropteroate synthase, the step immediately preceding this in the folate synthesis pathway.

Flashcard 685: Most Carbapenems are very useful against Pseudomonas aeruginosa, except _____ which has limited coverage

Answer: Ertapenem

Flashcard 686: Treatment for Streptococcus agalactiae (GBS) is _____

Answer: penicillin G (specific)

Flashcard 687: Which carbapenem has a decreased risk of seizure?_____

Answer: Meropenem

Flashcard 688: What cutaneous pathology can be treated with tetracyclines?_____

Answer: Acne

Flashcard 689: Isoniazid _____ cytochrome p450 (induces or inhibits)

Answer: inhibits

Flashcard 690: Pyrazinamide is a pro-drug that is converted into the active form, _____, by the enzyme pyrazinamidase

Answer: pyrazinoic acid