Antibiotics — Flashcards

Flashcard 631: Lowest concentration of an antibiotic that prevents visible growth of bacteria_____

Answer: Minimal inhibitory concentration (MIC)

Flashcard 632: What is the first line treatment of Borrelia burgdorferi (lyme disease)?_____

Answer: Doxycycline

Flashcard 633: Ceftriaxone is the DOC for what STD?_____

Answer: Gonorrhea

Flashcard 634: Which one of the following drugs is a cytochrome p450 inducer?_____

Answer: Rifampin

Flashcard 635: Which antibiotic can present with myopathy and rhabdomyolysis?_____

Answer: Daptomycin

Flashcard 636: What non-3rd generation group of cephalosporins can be used to treat bacterial meningitis?_____

Answer: 4th gen. Cefepime

Flashcard 637: Isoniazid is metabolized by the hepatic enzyme _____

Answer: N-acetyltransferase

Flashcard 638: Rifampin use is associated with _____-toxicity

Answer: hepato

Flashcard 639: Which step of bacterial genetics do Rifamycins impact?

Answer: Transcription (Inhibit DNA-dependent RNA polymerase)

Flashcard 640: What is the mechanism of action of the Streptogramin combination **Quinupristin-Dalfopristin**?

Answer: Inhibits bacterial protein synthesis by binding to the **50S subunit**: 1. **Dalfopristin**: Inhibits peptidyl transferase (peptide bond formation) 2. **Quinupristin**: Inhibits translocation (peptide exit)

Extra: Individually they are bacteriostatic, but the combination is bactericidal. Used for VRE (*E. faecium*) and MRSA.