Antibiotics — Flashcards

Flashcard 631: Which drug used for chronic gout is a sulfa drug?_____

Answer: Probenecid

Flashcard 632: Ceftriaxone is the DOC for what STD?_____

Answer: Gonorrhea

Flashcard 633: Isoniazid is metabolized by the hepatic enzyme _____

Answer: N-acetyltransferase

Flashcard 634: What is the mechanism of action of the Streptogramin combination **Quinupristin-Dalfopristin**?

Answer: Inhibits bacterial protein synthesis by binding to the **50S subunit**: 1. **Dalfopristin**: Inhibits peptidyl transferase (peptide bond formation) 2. **Quinupristin**: Inhibits translocation (peptide exit)

Extra: Individually they are bacteriostatic, but the combination is bactericidal. Used for VRE (*E. faecium*) and MRSA.

Flashcard 635: Disulfiram-like reaction is an adverse effect of what β-lactam antibiotics?

Answer: Cephalosporins

Flashcard 636: Which step of bacterial genetics do Rifamycins impact?

Answer: Transcription (Inhibit DNA-dependent RNA polymerase)

Flashcard 637: What non-3rd generation group of cephalosporins can be used to treat bacterial meningitis?_____

Answer: 4th gen. Cefepime

Flashcard 638: Treatment for Legionella pneumophila infection includes azithromycin (macrolides) or _____

Answer: levofloxacin, moxifloxacin (fluoroquinolones)

Flashcard 639: Which one of the following drugs is a cytochrome p450 inducer?_____

Answer: Rifampin

Flashcard 640: Which antibiotic can present with myopathy and rhabdomyolysis?_____

Answer: Daptomycin