Antibiotics — Flashcards

Flashcard 561: All Beta-lactam antibiotics are _____, as cell walls of bacteria are essential for growth and development.

Answer: bactericidal

Flashcard 562: Which etiology of meningitis is Pyrazinamide prescribed to treat?_____

Answer: M. tuberculosis

Flashcard 563: Vitamin K deficiency may occur due to long-term _____ therapy, which disrupts the gut flora

Answer: antibiotic

Flashcard 564: Isoniazid is administered with _____ in patients at risk for peripheral neuropathy as well as those who are pregnant, breastfeeding or have epilepsy.

Answer: pyridoxine (Vitamin B6)

Flashcard 565: Does the 5th generation cephalosporin ceftaroline have Pseudomonas coverage?

Answer: No

Extra: While the 4th generation cephalosporin (cefepime) covers Pseudomonas, the 5th generation (ceftaroline) does not. Note: Newer agents like ceftobiprole may have activity, but for exam purposes, ceftaroline is the 5th generation prototype and lacks anti-pseudomonal activity.

Flashcard 566: Resistance to macrolides (-thromycin) occurs via post-transcriptional methylation of the _____

Answer: 23S bacterial rRNA

Flashcard 567: Chronic alcohol use leads to _____ of CYP-450

Answer: induction

Flashcard 568: Clindamycin is bacterio-_____

Answer: static

Flashcard 569: What type of bacteria do carbapenems have activity towards?_____

Answer: Broad spectrum

Flashcard 570: Which enzyme is inhibited by trimethoprim (TMP)?_____

Answer: Dihydrofolate reductase (prokaryotic)