Molecular Genetics — Flashcards

Flashcard 341: Signal transducers relay receptor activation to the _____ (e.g. Ras)

Answer: nucleus

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Flashcard 342: What is the nucleoSide that is made with thymine? _____

Answer: Thymidine

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Flashcard 343: McCune-Albright syndrome is inherited in a(n) _____ fashion

Answer: non-inherited - somatic mutation

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Flashcard 344: _____ describes phenotypic variation among individuals with the same genotype

Answer: Variable expressivity

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Flashcard 345: What class of DNA-binding motif is common to cAMP response element binding (CREB) proteins? _____

Answer: Leucine zipper

Flashcard 346: What is the mechanism that results in malignancy from the PDGFB oncogene? _____

Answer: Overexpression

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Flashcard 347: What is the mode of inheritance of malignant hyperthermia? _____

Answer: Autosomal dominant

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Flashcard 348: The Ig heavy chain genes on chromosome 14 are _____ expressed

Answer: constitutively

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Flashcard 349: The APC tumor suppresor regulates the Wnt signalling pathway by destroying _____ in the absence of a Wnt receptor-ligand interaction

Answer: B-catenin

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Flashcard 350: What proteins compose the type 1 collagen triple helix (encoded by the COL1A1 & COL1A2 genes)?\n_____

Answer: 2 alpha-1 chains & 1 alpha-2 chains

Extra: Type I collagen is composed of two $\alpha$1 chains and one $\alpha$2 chain. Mutations in the COL1A1 or COL1A2 genes lead to Osteogenesis Imperfecta.