Molecular Genetics — Flashcards

Flashcard 341: McCune-Albright syndrome is inherited in a(n) _____ fashion

Answer: non-inherited - somatic mutation

Flashcard 342: What is the nucleoSide that is made with thymine? _____

Answer: Thymidine

Flashcard 343: _____ describes phenotypic variation among individuals with the same genotype

Answer: Variable expressivity

Flashcard 344: Signal transducers relay receptor activation to the _____ (e.g. Ras)

Answer: nucleus

Flashcard 345: What is the mechanism that results in malignancy from the PDGFB oncogene? _____

Answer: Overexpression

Flashcard 346: What class of DNA-binding motif is common to cAMP response element binding (CREB) proteins? _____

Answer: Leucine zipper

Flashcard 347: The Ig heavy chain genes on chromosome 14 are _____ expressed

Answer: constitutively

Extra: Other:

Flashcard 348: A(n) _____ is negatively charged DNA wrapped around the outside of positively charged proteins called histones

Answer: nucleosome (10 nm chromatin)

Flashcard 349: What class of enzymes cleaves nucleotides in the middle of a DNA strand? _____

Answer: Endonucleases

Flashcard 350: What proteins compose the type 1 collagen triple helix (encoded by the COL1A1 & COL1A2 genes)?\n_____

Answer: 2 alpha-1 chains & 1 alpha-2 chains

Extra: Type I collagen is composed of two $\alpha$1 chains and one $\alpha$2 chain. Mutations in the COL1A1 or COL1A2 genes lead to Osteogenesis Imperfecta.