Molecular Genetics — Flashcards

What is the mode of inheritance of malignant hyperthermia? _____

The APC tumor suppresor regulates the Wnt signalling pathway by destroying _____ in the absence of a Wnt receptor-ligand interaction

Hereditary spherocytosis most commonly involves defects in _____, spectrin, Band 3, or protein 4.2

A(n) _____ blot is used to identify DNA-binding proteins using labeled oligonucleotide probes

Hemochromatosis may be primary; due to _____ mutations in iron absorption

Hint: inheritance pattern

Which replication enzyme is a RNA-dependent DNA polymerase, and thus a major example of reverse transcriptase activity, in humans? _____

Mitochondrial diseases often demonstrate variable expression in a population or within a family due to _____

What is the effect of increased G-C content on the melting temperature of a DNA strand? _____

Hemoglobin C disease is caused by a mutation in the _____ chain of hemoglobin

A mutation at a(n) _____ results in a retained intron in the mRNA, leading to a protein with impaired or altered function