Molecular Genetics — Flashcards

Flashcard 821: What protein in hemidesmosomes binds to fibronectin, laminin, or collagen in the basement membrane? _____ *bonus-Ca2+ dependent? Y/N

Answer: Integrin Bonus: Yes (Ca2+ dependent)

Flashcard 822: _____ is a mutation that may occur spontaneously or due to heat or nitrates

Answer: Deamination (e.g. cytosine to uracil)

Flashcard 823: _____ describes the contribution of one gene to multiple phenotypic effects

Answer: Pleiotropy

Flashcard 824: How many ring(s) do purines have?_____

Answer: Two

Flashcard 825: β-thalassemia is usually caused by gene _____.

Answer: Mutations (specifically point mutations in splice sites and promoter sequences)

Extra: In contrast, **α-thalassemia** is usually caused by gene **deletions**.

Flashcard 826: The _____ subunits of the anterior pituitary hormones TSH, FSH, and LH are different and are responsible for the unique biologic activity of each hormone.

Answer: beta

Extra: The alpha subunits of TSH, LH, FSH, and hCG are identical. The beta subunit provides the biological specificity.

Flashcard 827: The _____ family of hormones includes: 1. ACTH 2. Melanocyte-stimulating hormone (MSH) 3. Gamma and beta-lipotropin 4. Beta-endorphin

Answer: Pro-opiomelanocortin (POMC)