Molecular Genetics — Flashcards

Flashcard 811: Do patients with α-thalassemia due to a four-gene deletion have any α-globin? _____

Answer: No

Flashcard 812: If a mother has a mitochondrial disease, all her children are _____

Answer: affected

Flashcard 813: The _____ family of hormones includes: 1. ACTH 2. Melanocyte-stimulating hormone (MSH) 3. Gamma and beta-lipotropin 4. Beta-endorphin

Answer: Pro-opiomelanocortin (POMC)

Flashcard 814: Which class of histone is not found as a pair in a nucleosome? _____

Answer: H1

Flashcard 815: The _____ subunits of the anterior pituitary hormones TSH, FSH, and LH are different and are responsible for the unique biologic activity of each hormone.

Answer: beta

Extra: The alpha subunits of TSH, LH, FSH, and hCG are identical. The beta subunit provides the biological specificity.

Flashcard 816: What protein in hemidesmosomes binds to fibronectin, laminin, or collagen in the basement membrane? _____ *bonus-Ca2+ dependent? Y/N

Answer: Integrin Bonus: Yes (Ca2+ dependent)

Flashcard 817: How many ring(s) do purines have?_____

Answer: Two

Flashcard 818: In an autosomal dominant inheritance pattern, the disease usually _____ skip generations.

Answer: does not

Flashcard 819: What is the mode of inheritance of cystic fibrosis? _____

Answer: Autosomal recessive

Flashcard 820: β-thalassemia is usually caused by gene _____.

Answer: Mutations (specifically point mutations in splice sites and promoter sequences)

Extra: In contrast, **α-thalassemia** is usually caused by gene **deletions**.