Molecular Genetics — Flashcards

Flashcard 811: Primary lactase deficiency occurs due to absence of the _____ allele

Answer: lactase-persistent

Flashcard 812: What type of gene is the BTK gene?_____

Answer: Tyrosine kinase

Flashcard 813: Do patients with α-thalassemia due to a four-gene deletion have any α-globin? _____

Answer: No

Flashcard 814: The _____ subunits of the anterior pituitary hormones TSH, FSH, and LH are different and are responsible for the unique biologic activity of each hormone.

Answer: beta

Extra: The alpha subunits of TSH, LH, FSH, and hCG are identical. The beta subunit provides the biological specificity.

Flashcard 815: _____ are a laboratory technique used to profile gene expression levels of thousands of genes simultaneously to study certain diseases and treatments

Answer: Microarrays

Flashcard 816: What protein in hemidesmosomes binds to fibronectin, laminin, or collagen in the basement membrane? _____ *bonus-Ca2+ dependent? Y/N

Answer: Integrin Bonus: Yes (Ca2+ dependent)

Flashcard 817: _____ is a mutation that may occur spontaneously or due to heat or nitrates

Answer: Deamination (e.g. cytosine to uracil)

Flashcard 818: What is the mode of inheritance of cystic fibrosis? _____

Answer: Autosomal recessive

Flashcard 819: What class of diseases is Huntington disease a part of?_____

Answer: Trinucleotide repeat expansion diseases

Flashcard 820: The _____ family of hormones includes: 1. ACTH 2. Melanocyte-stimulating hormone (MSH) 3. Gamma and beta-lipotropin 4. Beta-endorphin

Answer: Pro-opiomelanocortin (POMC)