Metabolism — Flashcards

Flashcard 61: Which metabolic pathway is isocitrate dehydrogenase part of?

Answer: TCA cycle (Rate-limiting enzyme)

Extra: Activators: ADP, Ca2+ Inhibitors: ATP, NADH

Flashcard 62: fructose-1,6-bisphosphatase (FBP-1)

Answer: gluconeogenesis

Extra: ATPAMP, fructose-2,6-BP

Flashcard 63: If an enyzme is a dehydrogenase, what do you know about its function?

Answer: catalyzes redox reaction

Flashcard 64: If an enyzme is a phosphatase, what do you know about its function?

Answer: removes phosphate group from substrate mnemonic: -tase takes away

Flashcard 65: What is the effect of alcohol metabolism on the NADH/NAD+ ratio in the liver?

Answer: increased NADH/NAD+ ratio

Flashcard 66: Outline the pathway for pyrimidine synthesis.

Answer: make temporary base (orotic acid) PRPP + orotic acid = UMP UMP can converted to CTP or dTMP

Flashcard 67: Outline the pathway for purine synthesis.

Answer: PRPP + base = IMP IMP converted to AMP or GMP (base may be salvaged or created de novo)

Flashcard 68: Zellweger syndrome is a result of mutations in _____ genes that encode for peroxins, which are required for normal assembly of peroxisomes

Answer: PEX

Flashcard 69: Which form of C5 convertase is produced via the lectin and classic complement pathways? _____

Answer: C4b2b3b

Flashcard 70: The _____ complex is a mitochondrial enzyme complex linking glycolysis and the TCA cycle

Answer: pyruvate dehydrogenase