Metabolism — Flashcards

Flashcard 61: Which metabolic pathway is isocitrate dehydrogenase part of?

Answer: TCA cycle (Rate-limiting enzyme)

Extra: Activators: ADP, Ca2+ Inhibitors: ATP, NADH

Flashcard 62: fructose-1,6-bisphosphatase (FBP-1)

Answer: gluconeogenesis

Extra: ATPAMP, fructose-2,6-BP

Flashcard 63: If an enyzme is a dehydrogenase, what do you know about its function?

Answer: catalyzes redox reaction

Flashcard 64: If an enyzme is a phosphatase, what do you know about its function?

Answer: removes phosphate group from substrate mnemonic: -tase takes away

Flashcard 65: What is the effect of alcohol metabolism on the NADH/NAD+ ratio in the liver?

Answer: increased NADH/NAD+ ratio

Flashcard 66: Outline the pathway for pyrimidine synthesis.

Answer: make temporary base (orotic acid) PRPP + orotic acid = UMP UMP can converted to CTP or dTMP

Flashcard 67: Outline the pathway for purine synthesis.

Answer: PRPP + base = IMP IMP converted to AMP or GMP (base may be salvaged or created de novo)

Flashcard 68: Zellweger syndrome is a result of mutations in _____ genes that encode for peroxins, which are required for normal assembly of peroxisomes

Answer: PEX

Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/biochemistry/videos/cell-biology?index=5] https://onlinemeded.org?ref=anki 

Flashcard 69: The _____ complex is a mitochondrial enzyme complex linking glycolysis and the TCA cycle

Answer: pyruvate dehydrogenase

Extra:    https://onlinemeded.org/spa/metabolism/pyruvate-dehydrogenase/acquire?ref=anki 

Flashcard 70: In Purine metabolism, purines end up being converted to _____, a substrate for xanthine oxidase

Answer: hypoxanthine

Extra:   Watch Purine Salvage Pathway [https://dashboard.sketchy.com/study/medical/courses/medical-biochemistry/units/medical-biochemistry-molecular-biology/videos/medical-biochemistry-molecular-biology-dna-purine-salvage-pathway?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical] Watch Gout drugs [https://dashboard.sketchy.com/study/medical/courses/medical-biochemistry/units/medical-biochemistry-molecular-biology/videos/medical-biochemistry-molecular-biology-dna-purine-salvage-pathway?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/genetics/videos/dna-structure?index=4] https://onlinemeded.org/spa/metabolism?ref=anki