Metabolism — Flashcards

Flashcard 1371: Vitamin B12 deficiency takes _____ to develop due to large hepatic stores

Answer: years

Flashcard 1372: Neuronal death in Huntington disease occurs via NMDA-R binding and _____ excitotoxicity

Answer: glutamate

Flashcard 1373: The pK of the HCO3-/CO2 buffer is _____

Answer: 6.1

Flashcard 1374: Does the metabolism of **cationic** amino acids (e.g., lysine, arginine) cause a change in blood pH? _____

Answer: Yes (decreased)

Extra: The metabolism of **cationic** amino acids (Arginine, Lysine, Histidine) and **sulfur-containing** amino acids (Methionine, Cysteine) results in the net production of fixed acids (H+), which decreases blood pH. Conversely, the metabolism of **anionic** amino acids (Glutamate, Aspartate) and other organic anions (like citrate or lactate) consumes H+, which increases blood pH.

Flashcard 1375: Is the conversion of ribulose-5-P into ribose-5-P (HMP shunt) a reversible or irreversible reaction? _____

Answer: Reversible

Flashcard 1376: Glucose-6-phosphate dehydrogenase (G6PD) is stimulated by _____

Answer: NADP+

Flashcard 1377: What vitamin is necessary for differentiation of specialized epithelial surfaces? _____

Answer: Vitamin A

Flashcard 1378: What do the carrier molecules NADH, NADPH, and FADH2 carry in their activated forms? _____

Answer: Electrons

Flashcard 1379: How does the activity of acetylcholinesterase change with lowered temperatures?_____

Answer: Decreased

Flashcard 1380: Methotrexate, 5-fluorouracil and hydroxyurea inhibit _____ synthesis

Answer: thymidine