Metabolism — Flashcards

Flashcard 1331: What is the rate-limiting enzyme for glycogenolysis? _____

Answer: Glycogen phosphorylase

Flashcard 1332: What is the primary role of vascular endothelial growth factor (VEGF)? _____

Answer: Angiogenesis / Vasculogenesis

Flashcard 1333: In total, the TCA cycle produces _____ FADH2 per acetyl-CoA

Answer: 1

Flashcard 1334: Factor X of the coagulation cascade may be activated by factor _____ (extrinsic pathway)

Answer: VIIa

Flashcard 1335: A _____ enzyme adds inorganic phosphate onto a substrate without using ATP

Answer: phosphorylase

Flashcard 1336: _____ are produced, predominantly by the liver, when growth hormones act on target tissue

Answer: Somatomedins (IGFs)

Flashcard 1337: _____ facilitate dissociation of GDP so that GTP can bind more rapidly, increasing the rate of G protein activation

Answer: Guanine nucleotide releasing factors (GRFs)

Flashcard 1338: The HMP shunt may be referred to as the _____ pathway

Answer: pentose phosphate

Flashcard 1339: What is the most common cause of oxidative stress in patients with G6PD deficiency?_____

Answer: Infection

Flashcard 1340: Homocystinuria can be caused by _____ deficiencies.

Answer: vitamin (B6, B9, or B12)

Extra: Classic homocystinuria is most commonly caused by an autosomal recessive deficiency of cystathionine beta-synthase (CBS). However, elevated homocysteine (and subsequent homocystinuria) can also be caused by deficiencies in B6 (pyridoxine), B9 (folate), or B12 (cobalamin).