Lipid metabolism US Medical PG Flashcards - Medical Study Cards
Master Lipid metabolism with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
Lipid metabolism Flashcard Deck - 10 Cards
Flashcard 161: The fungal cell membrane is composed of _____ as opposed to cholesterol
Answer: Ergosterol
Extra:
https://onlinemeded.org/spa/microbiology/fungi/acquire?ref=anki
Flashcard 162: Progesterone may be converted to _____ via the enzyme 17α-hydroxylase
Answer: 17-hydroxyprogesterone
Extra:
Watch Congenital Adrenal Hyperplasia (CAH) [https://dashboard.sketchy.com/study/medical/courses/medical-pathophysiology/units/medical-pathophysiology-endocrine/videos/medical-pathophysiology-endocrine-adrenal-disorders-congenital-adrenal-hyperplasia-cah?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]
https://onlinemeded.org/spa/endocrinology/adrenals/acquire?ref=anki
Flashcard 163: In adipose tissue, triglycerides are broken down into glycerol and fatty acids by the enzyme _____
Answer: hormone sensitive lipase
Extra:
https://onlinemeded.org/spa/surgery-general/pancreas/acquire?ref=anki
Flashcard 164: Type IIa familial dyslipidemia is due to either:
- absent or defective _____
- defective Apo B-100
Answer: LDL receptors
Extra:
https://onlinemeded.org/spa/metabolism?ref=anki
Flashcard 165: The triglycerides inside the chylomicron are broken down into _____ by lipoprotein lipase in the vicinity of the adipocytes (or peripheral tissue)
Answer: fatty acids
Extra:
https://onlinemeded.org/spa/metabolism?ref=anki
Flashcard 166: Niacin (Vitamin B3) decreases serum triglycerides by decreasing hepatic _____ secretion
Answer: VLDL
Extra: Mechanism of Niacin (Vitamin B3):
1. Adipose tissue: Inhibits hormone-sensitive lipase (HSL) → ↓ lipolysis → ↓ free fatty acids (FFAs) delivered to the liver.
2. Liver: ↓ hepatic VLDL synthesis and secretion (due to decreased FFA substrate and inhibition of DGAT2).
3. Plasma: ↓ LDL (downstream effect of ↓ VLDL) and ↑↑ HDL (by inhibiting the hepatic uptake/catabolism of ApoA-I).
Sketchy Pharmacology: Blood & Inflammation (Dyslipidemia drugs - Fibrates, Niacin)
Flashcard 167: Increased levels of cholesterol inside the hepatocyte leads to decreased activity of the enzyme _____
Answer: HMG-CoA reductase
Extra:
https://onlinemeded.org/spa/metabolism?ref=anki
Flashcard 168: Which lysosomal storage disease may be treated with recombinant enzyme therapy?
_____
Answer: Gaucher disease (i.e. recombinant glucocerebrosidase)
Extra:
https://onlinemeded.org/spa/metabolism?ref=anki
Flashcard 169: Once in the vicinity of adipocytes, apoprotein _____ on the chylomicron activates the enzyme lipoprotein lipase (LPL)
Answer: C-II
Extra:
https://onlinemeded.org/spa/metabolism?ref=anki
Flashcard 170: Acetyl-CoA is converted to _____ via the enzyme acetyl-CoA carboxylase (fatty acid synthesis)
Answer: malonyl-CoA
Extra:
Watch Fatty Acid Synthesis [https://dashboard.sketchy.com/study/medical/courses/medical-biochemistry/units/medical-biochemistry-metabolism/videos/medical-biochemistry-metabolism-lipids-fatty-acid-synthesis?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]
https://onlinemeded.org/spa/metabolism?ref=anki
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