Drugs Affecting Blood and Blood Formation — Flashcards

_____ is an anti-coagulant that intereferes with -carboxylation of vitamin K-dependent clotting factors (II, VII, IX, X)

_____ to heparin shows therapeutic anti-factor Xa levels with a subtherapeutic aPTT. (therapeutic/subtherapeutic)

Hint: Resistance/Pseudo-resistance

_____ is a preformed complex of plasminogen and streptokinase.

PDE inhibitors (e.g. cilostazol, dipyridamole) _____ cAMP, which inhibits platelet aggregation

Thrombolytics result in an _____ PT and elevated PTT

_____ to heparin shows subtherapeutic anti-factor Xa levels with a subtherapeutic aPTT. (therapeutic/subtherapeutic)

Hint: Resistance/Pseudo-resistance

Prostaglandin _____ causes decreased platelet aggregation

Which clotting factors are inactivated by the low molecular weight heparin (LMWH)? Mostly _____, but also Thrombin, Factor XIa, and Factor IXa

The anti-coagulants _____ and S are reduced early in warfarin therapy, leading to a hyper-coaguable state

_____ receptors (PAR-1), are activated by thrombin and contributes to platelet aggregation