Drugs Affecting Blood and Blood Formation — Flashcards
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_____ is a competitive antagonist of PAR-1
Heparin-induced thrombocytopenia occurs due to production of Ig_____ antibodies against heparin-platelet factor IV complexes
Treatment of hemophilia A involves _____ plus recombinant factor VIII
_____ is an anticoagulant that acts only on factor Xa
What drugs are used to reverse the effects of thrombolytics?_____ and tranexamic acid
_____ is considered superior to all other parenteral iron supplementation especially for postpartum IDA.
Immune thrombocytopenia can be treated with the TPO receptor agonists _____ and romiplostim
Treatment for disorders of fibrinolysis is _____, which blocks activation of plasminogen
_____ is a nonspecific PDE inhibitor that prevents adenosine reuptake in platelets to cause vasodilation.
Sirolimus (rapamycin) is an immunosuppresant that blocks _____ cell activation via blocking a step in the IL-2 receptor signaling pathway
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Drugs Affecting Blood and Blood Formation Flashcard Deck - 86 Cards
Flashcard 1: _____ is a competitive antagonist of PAR-1
Answer: Vorapaxar
Flashcard 2: Heparin-induced thrombocytopenia occurs due to production of Ig_____ antibodies against heparin-platelet factor IV complexes
Answer: G
Flashcard 3: Treatment of hemophilia A involves _____ plus recombinant factor VIII
Answer: desmopressin
Flashcard 4: _____ is an anticoagulant that acts only on factor Xa
Answer: Fondaparinux
Flashcard 5: What drugs are used to reverse the effects of thrombolytics?_____ and tranexamic acid
Answer: aminocaproic acid
Flashcard 6: _____ is considered superior to all other parenteral iron supplementation especially for postpartum IDA.
Answer: Ferric carboxymaltose
Flashcard 7: Immune thrombocytopenia can be treated with the TPO receptor agonists _____ and romiplostim
Answer: eltrombopag
Flashcard 8: Treatment for disorders of fibrinolysis is _____, which blocks activation of plasminogen
Answer: aminocaproic acid
Flashcard 9: _____ is a nonspecific PDE inhibitor that prevents adenosine reuptake in platelets to cause vasodilation.
Answer: Dipyridamole
Flashcard 10: Sirolimus (rapamycin) is an immunosuppresant that blocks _____ cell activation via blocking a step in the IL-2 receptor signaling pathway
Answer: T
Flashcard 11: _____ is an ADP receptor antagonist associated with granulocytopenia as an adverse effect
Answer: Ticlopidine
Flashcard 12: Iron chelators are indicated for _____ and iron poisoning
Answer: secondary hemochromatosis
Flashcard 13: _____ is a drug that inhibits the enzyme epoxide reductase
Answer: Warfarin (coumadin)
Flashcard 14: Aspirin irreversibly inactivates the enzyme _____, thus decreasing synthesis of TXA2 and impairing platelet aggregation
Answer: cyclooxygenase
Flashcard 15: Bone marrow suppression caused by Zidovudine can be reversed with _____ and erythropoietin
Answer: G-CSF
Flashcard 16: Lesch-Nyhan syndrome is treated with _____ or febuxostat (2nd line)
Answer: allopurinol
Flashcard 17: Desmopressin increases release of _____ from Weibel-Palade bodies
Answer: vWF
Flashcard 18: _____ acts as an antisense oligonucleotide inhibitor of apo B-100 synthesis.
Answer: Mipomersen
Flashcard 19: _____ is given to treat thrombocytopenia secondary to anti-cancer therapy.
Answer: Oprelvekin
Flashcard 20: What are the routes of administration (2) of heparin? _____ (acute) or subcutaneous (prophylaxis)
Answer: IV
Flashcard 21: CXCR-4 _____ indicated for peripheral blood stem cell mobilization is plerixafor
Answer: antagonist
Flashcard 22: Vitamin _____ is the specific antidote for warfarin but it takes 6-24 hours for the clotting factors to be resynthesized
Answer: K1
Flashcard 23: Abciximab is an _____ therapy used in patients undergoing PCI in order to prevent ischemic complications
Answer: antiplatelet
Flashcard 24: In _____ deficiency, PTT doesn't rise with standard heparin dosing
Answer: ATIII
Flashcard 25: Deferoxamine, deferasirox, and deferiprone are _____ chelators
Answer: iron
Flashcard 26: Hematological complications of Trimethoprim (TMP) use include _____ (granulocytopenia, leukopenia) and megaloblastic anemia
Answer: pancytopenia
Flashcard 27: The goal INR for warfarin therapy is typically between _____ - 3
Answer: 2
Flashcard 28: _____ is a compound that binds free phosphate in the gastrointestinal tract
Answer: Sevelamer
Flashcard 29: Interferon _____ may be used to treat chronic granulomatous disease (CGD)
Answer: gamma
Flashcard 30: Thrombolytics result in an _____ PT and elevated PTT
Answer: elevated
Flashcard 31: _____ to heparin shows subtherapeutic anti-factor Xa levels with a subtherapeutic aPTT. (therapeutic/subtherapeutic)
Answer: Resistance
Flashcard 32: _____ is an anti-coagulant that intereferes with -carboxylation of vitamin K-dependent clotting factors (II, VII, IX, X)
Answer: Warfarin
Flashcard 33: _____ to heparin shows therapeutic anti-factor Xa levels with a subtherapeutic aPTT. (therapeutic/subtherapeutic)
Answer: Pseudo-resistance
Flashcard 34: _____ is a preformed complex of plasminogen and streptokinase.
Answer: Anistreptlase
Flashcard 35: First Aid Pharmacology: Respiratory Epoprostenol and iloprost _____ platelet aggregation
Answer: inhibit
Flashcard 36: PDE inhibitors (e.g. cilostazol, dipyridamole) _____ cAMP, which inhibits platelet aggregation
Answer: increase
Flashcard 37: Fibrates significantly decrease serum _____ by increasing hydrolysis of VLDLs and chylomicrons
Answer: triglycerides
Flashcard 38: Which clotting factors are inactivated by the low molecular weight heparin (LMWH)? Mostly _____, but also Thrombin, Factor XIa, and Factor IXa
Answer: Factor Xa
Flashcard 39: _____ receptors (PAR-1), are activated by thrombin and contributes to platelet aggregation
Answer: Protease activated
Flashcard 40: Prostaglandin _____ causes decreased platelet aggregation
Answer: I2 (prostacyclin)
Flashcard 41: The anti-coagulants _____ and S are reduced early in warfarin therapy, leading to a hyper-coaguable state
Answer: protein C
Flashcard 42: Binding of ADP to the P2Y12 receptor leads to _____ cAMP formation which favors platelet activation
Answer: decreased
Flashcard 43: _____is a concern when desmopressin is used in bleeding disorders
Answer: Tachyphylaxis
Flashcard 44: For rapid reversal of warfarin, _____ or prothrombin complex concentrates (PCC) should be administered
Answer: fresh frozen plasma (FFP)
Flashcard 45: _____ to heparin occurs due to increased levels of plasma proteins that compete with heparin or due to decreased antithrombin levels
Answer: Resistance
Flashcard 46: The effect of low dose aspirin _____ mg/day is decreased platelet aggregation.
Answer: <300
Flashcard 47: The B6 depletion with Isoniazid use can lead to decreased _____ synthesis, leading to a sideroblastic anemia.
Answer: protoporphyrin
Flashcard 48: Concomitant measurement of _____ and anti-factor Xa level distinguishes pseudo-resistance and true-resistance to heparin.
Answer: aPTT
Flashcard 49: Methemoglobinemia can be treated by _____ and vitamin C
Answer: methylene blue
Flashcard 50: _____ is a synthetic plasma kallikrein inhibitor
Answer: Ecallantide
Flashcard 51: What is the mechanism of action of Fondaparinux?_____
Answer: Antithrombin activation
Flashcard 52: Type _____ HIT is due to direct platelet aggregating effects of Heparin
Answer: I
Flashcard 53: Ticlopidine, Clopidogrel, Prasugrel are _____ P2Y12 inhibitors
Answer: irreversible (irreversible/reversible)
Flashcard 54: _____ approved for the treatment of thrombocytopenia with chronic liver disease.
Answer: Avatrombopag
Flashcard 55: _____ is an inhibitor of hemoglobin S polymerase
Answer: Voxelotor
Flashcard 56: _____ is a synthetic cationic molecule that binds to heparin, LMWH, dabigatran, and oral factor Xa inhibitors
Answer: Ciraparantag
Flashcard 57: Which P2Y12 inhibitor drugs are prodrugs? (3)_____
Answer: Clopidogrel, Prasugrel and Ticlopidine
Flashcard 58: LMWH and fondaparinux are given _____.
Answer: subcutaneously (route)
Flashcard 59: Which oral thrombin inhibitor is contraindicated in patients with mechanical heart valves?_____
Answer: Dabigatran
Flashcard 60: _____ is a thrombopoietin receptor agonist approved for the treatment of thrombocytopenia with chronic liver disease
Answer: Avatrombopag
Flashcard 61: _____ is an erythroid maturation agent, recently approved by the FDA for the treatment of transfusion-dependent thalassemia.
Answer: Luspatercept
Flashcard 62: Type I HIT is _____ common than Type II HIT
Answer: more
Flashcard 63: _____ is an oral HIF prolyl hydroxylase inhibitor, used to treat anemia in CKD.
Answer: Daprodustat
Flashcard 64: What is a recently approved non-salt-based iron preparation with fewer gastrointestinal side effects given orally?_____
Answer: Ferric maltol
Flashcard 65: Procoagulant drugs such as _____ can be used in hemoptysis if there is an abnormal coagulation profile
Answer: vasopressin
Flashcard 66: _____ is the drug of choice in cerebral venous thrombosis.
Answer: IV heparin
Flashcard 67: Dicoumarol inhibits the action of vitamin K by _____ inhibition.
Answer: competitive
Flashcard 68: _____ prophylaxis is recommended for prophylaxis in pregnant women who are on antiepileptic drugs having enzyme-inducing properties.
Answer: Vitamin K
Flashcard 69: Which GpIIb/IIIa inhibitors are contraindicated in renal failure?_____
Answer: Eptafibatide and Tirofiban (2)
Flashcard 70: Which tPA (fibrinolytic) has the lowest incidence of intracranial hemorrhage?_____
Answer: Streptokinase
Flashcard 71: Which r-tPA (fibrinolytic) has most affinity towards plasminogen bound to fibrin?_____
Answer: Tenecteplase
Flashcard 72: Ticagrelor, Cangrelor are _____ P2Y12 inhibitors
Answer: reversible (irreversible/reversible)
Flashcard 73: _____ is a monoclonal antibody directed against P-selectin, and reduces vaso-occlusive pain in sickle cell disease
Answer: Crizanlizumab
Flashcard 74: Most commercial preparations of heparin are extracted from _____ intestinal mucosa.
Answer: porcine (animal)
Flashcard 75: _____ is a competitive antagonist of _____ and inhibits thrombin-induced platelet aggregation.
Answer: Vorapaxar; PAR-1
Flashcard 76: Rivaroxaban is a direct _____ factor Xa inhibitor.
Answer: oral::route
Flashcard 77: Ferrous sucrose or iron sucrose is an preparation of _____ iron
Answer: parenteral::Route
Flashcard 78: _____ anemia is seen with nitrous oxide
Answer: Megaloblastic
Flashcard 79: IV _____ is an iron chelator indicated in patients with metabolic acidosis
Answer: deferoxamine
Flashcard 80: Cephalosporins that contain a _____ group can cause hypoprothrombinemia (factor II) and thereby bleeding problems.
Answer: methylthiotetrazole (NMTT)
Flashcard 81: _____ is a competitive antagonist of _____ and inhibits thrombin-induced platelet aggregation.
Answer: Vorapaxar; PAR-1
Flashcard 82: _____ has the least incidence of osteoporosis after prolonged use.
Answer: Fondaparinux::Anti-coagulant
Flashcard 83: Purple toe syndrome is an adverse effect of _____.
Answer: warfarin
Flashcard 84: Drug of choice for warfarin toxicity:
Answer: Vitamin K (Phytonadione)
Flashcard 85: Drug of choice for Neutropenia due to cancer chemotherapy:
Answer: Granulocyte colony-stimulating factor (G-CSF)
Flashcard 86: Drug of choice for Neutropenia due to cancer chemotherapy is -
Answer: Filgrastim
Keywords: Drugs Affecting Blood and Blood Formation flashcards, medical flashcards, NEET PG preparation, USMLE Step 1 flashcards, Anki alternative, spaced repetition medical, OnCourse flashcards
Study by Chapter
Hematopoietic Growth Factors
Flashcards
Iron Preparations and Management of Iron Deficiency
Flashcards
Vitamin B12 and Folic Acid
Flashcards
Anticoagulants: Heparins and Direct Inhibitors
Flashcards
Oral Anticoagulants
Flashcards
Antiplatelet Drugs
Flashcards
Thrombolytic Agents
Flashcards
Hemostatic Drugs
Flashcards
Plasma Expanders
Flashcards
Blood Transfusion and Alternatives
Flashcards
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