Clinical Pharmacology and Drug Toxicity — Flashcards

Hypersensitivity reactions are common with Sulfa drug use; result in fever, hypotension, _____ and rash

_____ interstitial nephritis is typically seen with patients who've been taking NSAIDs for a long time

Methemoglobinemia can be treated with _____ or vitamin C

What effect may NSAIDs have on K+ levels? _____

Drugs that prolong the QT interval (**ABCDEF+N**): **A** - Anti-arrhythmics (Class _____ and 3); Arsenic **B** - Anti-biotics (macrolides, fluoroquinolones) **C** - Anti-"c"ychotics (haloperidol); chloroquine **D** - Anti-depressants (TCAs); diuretics (thiazides) **E** - Anti-emetics (e.g., ondansetron) **F** - Anti-fungals (fluconazole) **N** - -navir (protease inhibitors)

The ototoxicity of aminoglycosides can cause either _____ or cochlear damage

_____ (OPIDN) is due to inhibition of the enzyme neuropathy target esterase

If a patient has to start antiepileptics during pregnancy then the first-line drugs are _____ and lamotrigine.

Vancomycin is a known cause of _____-philia and skin rash

Intravenous _____ is an alternative to fomepizole in methanol toxicity.