Clinical Pharmacology and Drug Toxicity — Flashcards

Flashcard 21: adverse effects following tetanus toxoid are _____

Answer: brachial neuritis and anaphylaxis

Extra: 

Flashcard 22: killed vaccine for influenza is _____ based

Answer: egg

Extra: 

Flashcard 23: Contraindications for delamanid and bedaquiline include:

Answer: cardiac diseases pregnancy and lactation hypokalemia

Flashcard 24: What are the contraindications to the yellow fever vaccine?

Answer: 1. Severe egg allergy 2. Age < 6 months 3. Immunosuppression (e.g., HIV with CD4 < 200, chemotherapy) 4. Thymus disease (e.g., Myasthenia gravis, thymoma)

Extra: Yellow fever vaccine (17D strain) is a live-attenuated vaccine. It is grown in chick embryos. Specific contraindications like thymus disorders and age < 6 months (due to encephalitis risk) are high-yield.

Flashcard 25: Organochlorine poisoning has no specific antidote; seizures are managed with _____

Answer: barbiturates

Extra: There is no specific antidote for organochlorine poisoning; barbiturates (e.g., phenobarbital) are used to manage seizures.

Flashcard 26: contraindication of killed vaccine for influenza is _____

Answer: egg allergy

Extra: 

Flashcard 27: Valproic acid causes _____ appetite and weight gain

Answer: increased

Flashcard 28: Encephalopathy due to _____ poisoning typically occurs with blood lead levels >100 microgram/dl.

Answer: lead

Flashcard 29: Signs and symptoms of Strychnine poisoning (mnemonic: **CRAMP**): **C**_____ **R**eflexes increased **A**wful taste **M**ind is conscious **P**upils dilated

Answer: onvulsions

Flashcard 30: Chronic vitamin _____ toxicity may cause arthralgias (joint complication)

Answer: A