Neuropathology — Flashcards

Flashcard 81: _____ Cancer can produce anti-Hu antibodies which can cause both Paraneoplastic Cerebellar Degeneration and Paraneoplastic Encephalomyelitis

Answer: Small Cell Lung

Flashcard 82: What neurotransmitters are decreased in Huntington disease? _____, GABA, and substance P

Answer: Acetylcholine

Flashcard 83: _____ - considered to be the most reliable indicator of axon damage in Diffuse Axonal Injury

Answer: Beta-amyloid precursor protein

Flashcard 84: _____ disease is associated with increased 14-3-3 protein in CSF

Answer: Creutzfeldt-Jakob

Flashcard 85: CNS involvement of disseminated Mycobacterium tuberculosis can result in _____ as well as caseating mass lesions known as tuberculomas

Answer: meningitis

Flashcard 86: The _____ and fifth cortical layers are best for displaying the histological changes of hypoxia.

Answer: third

Extra: This pattern of selective neuronal loss is known as **pseudolaminar necrosis**. The most sensitive cells to hypoxia/ischemia in the CNS are: 1. **Pyramidal cells** of the hippocampus (**Sommer sector/CA1**) and neocortex (**layers III, V, and VI**). 2. **Purkinje cells** of the cerebellum. 3. Striatal neurons.

Flashcard 87: One histological feature seen after an ischemic stroke is the presence of _____ and vascular proliferation, which appear between 1 - 2 weeks

Answer: reactive gliosis

Flashcard 88: _____ is the most common epithelial lacrimal gland tumor.

Answer: Pleomorphic adenoma

Flashcard 89: Nasal gliomas have a _____ consistency

Answer: firm

Flashcard 90: What is the gold standard for the diagnosis of Pure Neuritic Leprosy?_____

Answer: Nerve biopsy