Neuropathology — Flashcards

Flashcard 81: _____ bands of IgG on high resolution electrophoresis is diagnostic of multiple sclerosis

Answer: Oligoclonal

Flashcard 82: _____ atrophy is the congenital degeneration of the anterior horns of the spinal cord

Answer: Spinal muscular

Flashcard 83: Neurofibromatosis type II is associated with mutations in the _____ tumor suppressor gene on chromosome 22

Answer: NF2

Flashcard 84: Pilocytic astrocytoma is a _____, well-circumscribed tumor of astrocytes

Answer: benign

Flashcard 85: The _____ and fifth cortical layers are best for displaying the histological changes of hypoxia.

Answer: third

Extra: This pattern of selective neuronal loss is known as **pseudolaminar necrosis**. The most sensitive cells to hypoxia/ischemia in the CNS are: 1. **Pyramidal cells** of the hippocampus (**Sommer sector/CA1**) and neocortex (**layers III, V, and VI**). 2. **Purkinje cells** of the cerebellum. 3. Striatal neurons.

Flashcard 86: Schwannoma is a _____ tumor of Schwann cells

Answer: benign

Flashcard 87: _____ encephalopathy is a degenerative disease due to abnormal prion proteins

Answer: Spongiform

Flashcard 88: _____ is the most common epithelial lacrimal gland tumor.

Answer: Pleomorphic adenoma

Flashcard 89: Nasal gliomas have a _____ consistency

Answer: firm

Flashcard 90: What is the gold standard for the diagnosis of Pure Neuritic Leprosy?_____

Answer: Nerve biopsy