Neuropathology — Flashcards

Flashcard 21: _____ (CNS tumor) may cause precocious puberty in males due to β-hCG production

Answer: Pinealoma

Extra: Germinomas are the most common type of pineal gland tumor. In males, high levels of β-hCG (which is a structural analog of LH) can stimulate Leydig cells to produce testosterone, leading to precocious puberty.

Flashcard 22: Glioblastoma multiforme (GBM) is a _____, high-grade tumor of astrocytes

Answer: malignant

Flashcard 23: Multiple sclerosis is an _____ destruction of CNS myelin and oligodendrocytes

Answer: autoimmune

Flashcard 24: Rabies virus **Negri bodies** are most commonly found in the _____ (pyramidal cells) and the cerebellum (Purkinje cells).

Answer: hippocampus

Flashcard 25: One histological feature seen after an ischemic stroke is the presence of _____, which appear between 12 - 24 hours

Answer: red neurons

Flashcard 26: _____ to a site of CNS or PNS axon injury there is retrograde degeneration

Answer: Proximal

Flashcard 27: Gross pathology of _____ infection appears as 'soap-bubble' lesions in the gray matter of the brain

Answer: Cryptococcus

Flashcard 28: What is the prognosis of glioblastoma multiforme? _____

Answer: Poor

Flashcard 29: _____ is a CNS tumor that arises from epithelial remnants of Rathke's pouch (oral ectoderm)

Answer: Craniopharyngioma

Flashcard 30: _____ ischemic strokes result in a hemorrhagic (red) infarct at the periphery of the cortex

Answer: Embolic