Molecular Pathology — Flashcards

Which gene is usually mutated in Her2 enriched subtype of breast cancer?_____

Alveolar rhabdomyosarcoma frequently contains fusions of the _____ gene to either the PAX3 or the PAX7 gene

What is the first cancer to be directly associated with genetic abnormality?_____

Gain-of-function mutation in _____ is responsible for bladder carcinoma.

Translocations involving cyclin D1 or D3, hyperdiploidy, t(11;14), t(6;14) in multiple myeloma is associated with a _____ prognosis

Mutations in _____ signalling pathway is associated with Basal cell carcinoma

_____ is the most commonly mutated gene in sporadic breast carcinomas

FISH may be carried out in Metaphase or _____phase of the cell cycle.

_____ of function mutations in RET proto-oncogene occurs in MEN 2A syndrome.

_____ is the most commonly used chromogen in immunohistochemistry.