Pharmacogenomics — Flashcards

_____ is the most commonly mutated gene in sporadic breast carcinomas

The size of M-BCR ABL (Major BCR) protein in t(9;22) associated with chronic myeloid leukemia (CML) is _____ kDa.

Alagille syndrome is associated with mutations in the _____ gene in a small minority (<1%) of patients.

Activating mutation in _____ is responsible for bladder carcinoma.

_____ is a molecular test in breast cancer that is a 21-gene assay

Best's disease is caused by a mutation on a _____ gene.

In Array based Comparative Genomic Hybridization, if the test sample has amplification, then some spots on the array will fluoresce _____.

Gain-of-function mutations in _____ gene has been linked with Pityriasis Rubra Pilaris (PRP)

_____ syndrome is most commonly characterized by a 47,XXY karyotype

_____ syndrome is a disease from abnormal biogenesis of lysosome-related organelles with impaired melanosome maturation and absent dense bodies in thrombocytes.