Polymerase Chain Reaction Applications — Flashcards

10 flashcards

In Array based Comparative Genomic Hybridization, if the test sample has deletion, then some spots on the array will fluoresce _____

In Array based Comparative Genomic Hybridization, if the test sample has amplification, then some spots on the array will fluoresce _____.

What is the mode of diagnosis of Duchenne muscular dystrophy?_____

Which molecular test for breast cancer can be used for both ER/PR positive and hormone-receptor negative cancers?_____

The presence of _____ mutation is associated with poor prognosis in chronic lymphocytic leukemia (CLL)

_____ syndrome is due to an inherited defect in DNA mismatch repair enzymes, resulting in microsatellite instability

_____ syndrome is a disease from abnormal biogenesis of lysosome-related organelles with impaired melanosome maturation and absent dense bodies in thrombocytes.

In _____, 24 distinct fluorescent colours are made by mixing 5 fluorophores and each chromosome is identified by a unique colour.

_____ syndrome is most commonly characterized by a 47,XXY karyotype

#10

_____ syndrome is caused by a defect in fibrillin, a glycoprotein that forms a sheath around elastin

Polymerase Chain Reaction Applications Indian Medical PG Flashcards - Medical Study Cards

Master Polymerase Chain Reaction Applications with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.

Polymerase Chain Reaction Applications Flashcard Deck - 10 Cards

Flashcard 1: In Array based Comparative Genomic Hybridization, if the test sample has deletion, then some spots on the array will fluoresce _____

Answer: Red

Extra: In Array-based Comparative Genomic Hybridization (aCGH), the standard color convention (as per Robbins Pathology) is: • **Test (Patient) DNA**: Labeled with **Green** fluorophore (Cy3) • **Reference (Control) DNA**: Labeled with **Red** fluorophore (Cy5) **Interpretation of Spots:** • **Red**: Indicates a **deletion** (loss) in the test DNA (more reference DNA bound). • **Green**: Indicates an **amplification** (gain) in the test DNA (more patient DNA bound). • **Yellow**: Indicates a **normal** (balanced) amount of DNA.

Flashcard 2: In Array based Comparative Genomic Hybridization, if the test sample has amplification, then some spots on the array will fluoresce _____.

Answer: green

Flashcard 3: What is the mode of diagnosis of Duchenne muscular dystrophy?_____

Answer: PCR

Flashcard 4: Which molecular test for breast cancer can be used for both ER/PR positive and hormone-receptor negative cancers?_____

Answer: Mammaprint

Flashcard 5: The presence of _____ mutation is associated with poor prognosis in chronic lymphocytic leukemia (CLL)

Answer: NOTCH1

Flashcard 6: _____ syndrome is due to an inherited defect in DNA mismatch repair enzymes, resulting in microsatellite instability

Answer: Lynch

Flashcard 7: _____ syndrome is a disease from abnormal biogenesis of lysosome-related organelles with impaired melanosome maturation and absent dense bodies in thrombocytes.

Answer: Hermansky Pudlak

Flashcard 8: In _____, 24 distinct fluorescent colours are made by mixing 5 fluorophores and each chromosome is identified by a unique colour.

Answer: Multicolour FISH

Flashcard 9: _____ syndrome is most commonly characterized by a 47,XXY karyotype

Answer: Klinefelter

Flashcard 10: _____ syndrome is caused by a defect in fibrillin, a glycoprotein that forms a sheath around elastin

Answer: Marfan

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Polymerase Chain Reaction Applications Flashcards for NEET-PG

Study 10 flashcards on Polymerase Chain Reaction Applications for NEET-PG Pathology. These active recall cards cover the key concepts, clinical associations, and high-yield facts from this chapter of Molecular Pathology. Each card is designed to test your understanding rather than just recognition, building stronger and more durable memories for exam day.

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There are 10 flashcards for Polymerase Chain Reaction Applications, covering the key concepts, clinical correlations, and high-yield facts from this chapter of Molecular Pathology.

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