Dermatopathology — Flashcards

Flashcard 1: _____ has a characteristic histopathology of "Claw clutching a Ball' appearance

Answer: Lichen nitidus

Flashcard 2: What type of nevus shows lymphocytic infiltration surrounding nevus cells? _____

Answer: Halo nevus

Flashcard 3: _____ giant cells are lipid-containing macrophages, having a central ring of nuclei while the peripheral cytoplasm is clear due to accumulated lipid

Answer: Touton

Flashcard 4: Upward elongation of the dermal papillae, giving an accentuated and sometimes irregular, undulating configuration to the dermal–epidermal junction is known as _____

Answer: papillomatosis

Flashcard 5: _____ nevus is a non-nested dermal infiltration of highly dendritic heavily pigmented nevus cells

Answer: Blue

Flashcard 6: The following image shows malignant epithelial cells in the epidermis of the nipple, which is representative of _____

Answer: Paget's disease

Flashcard 7: The following image shows large cells in the epidermis with a clear halo, which are characteristic of _____ disease

Answer: Paget

Flashcard 8: mitsuda reaction is read at _____ days

Answer: 21

Extra: 

Flashcard 9: Inflammation in _____-myositis is mediated by CD-4+ T cells

Answer: dermato

Flashcard 10: In diabetic dermopathy, histology shows hyperpigmentation of _____ layer of epidermis along with deposition of haemosiderin and melanin in the dermis

Answer: basal

Flashcard 11: Molluscum contagiosum can present with histologic _____-philic cytoplasmicinclusion bodies within keratino-cytes of stratum spinosum and granulosum

Answer: eosino

Flashcard 12: _____ disease (of the vulva and nipple) is characterized by malignant epithelial cells in the epidermis

Answer: Paget

Flashcard 13: _____ bodies are eosinophilic globules seen in the epidermis or in the region of the dermalepidermal junction in spindle/epithelioid cell (Spitz) naevi

Answer: Kamino

Flashcard 14: _____ may be associated with Munro microabscesses, which are collections of neutrophils in the stratum corneum

Answer: Psoriasis

Flashcard 15: Lichen sclerosus is characterized by _____ of the epidermis and fibrosis (sclerosis) of the dermis

Answer: thinning

Flashcard 16: _____ is defined as increased thickness of the stratum granulosum (e.g. Lichen planus)

Answer: Hypergranulosis

Flashcard 17: Lichen planus is characterized histologically by inflammation of the _____ junction with a 'saw-tooth' appearance

Answer: dermal-epidermal

Flashcard 18: _____ microabscess also called as spongiform pustules of Kogoj (deep; usually in the spinous/malpighian layer) are seen in psoriasis

Answer: Neutrophilic

Flashcard 19: Neurotization of nevus occurs due to progressive loss of _____ activity and acquisition of cholinesterase activity in deeper nervelike nevus cells

Answer: tyrosinase

Flashcard 20: Melanoma may be distinguished from extramammary paget disease of the vulva by the following immunohistological features: 1. PAS _____ 2. Keratin - 3. S100 +

Answer: -

Flashcard 21: What is the MOA of exfoliative toxin in Scalded-Skin Syndrome? Destroys _____ attachments in statum granulosum, causing skin to slough off

Answer: keratinocyte

Flashcard 22: Langerhans cells are positive for _____ and S100 on immunohistochemistry

Answer: CD1a

Flashcard 23: Extramammary paget disease of the vulva may be distinguished from melanoma by the following immunohistological features: 1. PAS _____ 2. Keratin + 3. S100 -

Answer: +

Flashcard 24: In regards to wrinkles of aging, there is _____ synthesis of collagen fibrils and increased crosslinking of collagen

Answer: decreased

Flashcard 25: Homogeneous, _____philic, rounded body resulting from degeneration and death of keratinocytes, is known as Civatte body

Answer: eosino

Flashcard 26: _____ leprosy presents as a spindle-cell proliferation with storiform pattern

Answer: Histioid

Flashcard 27: Cylindroma is due to mutation of _____ gene on chromosome 16q12-13

Answer: CYLD

Flashcard 28: Langerhans cells have a single large nucleus with a characteristic folded or grooved nucleus ( _____ appearance) with small inconspicuous nucleoli and an eosinophilic cytoplasm

Answer: coffee-bean

Flashcard 29: Grenz zone is absent in _____ leprosy because the dermal tuberculoid granulomas extend upto the epidermis, thus obstructing the Grenz zone

Answer: tuberculoid

Flashcard 30: _____ of nevus is a change that occurs when nevus cells become non pigmented and resemble neural tissue as they grow deep into the dermis

Answer: Neurotization

Flashcard 31: Papillary _____ is a disorder of anogenital mammary-like apocrine glands, which presents as a benign nodule on the labia majora or interlabial folds, and may ulcerate

Answer: hidradenoma

Flashcard 32: Irritant contact dermatitis is a type of type _____ hypersensitivity reaction

Answer: 1

Flashcard 33: _____ method is the most specific method for staining melanin and stains it brown black

Answer: Dihydroxyphenylalanine (DOPA)-oxidase

Flashcard 34: What type of dyskeratosis (benign/neoplastic) is seen in Bowen s disease, squamous cell carcinoma, and actinic keratosis? _____

Answer: Neoplastic

Flashcard 35: _____keratosis is characterized by nuclear pyknosis and condensation of the cytoplasm of keratinocytes.

Answer: Dys

Flashcard 36: Epidermis of an orf lesion shows ballooning degeneration of keratinocytes with eosinophilic _____ inclusions

Answer: cytoplasmic

Flashcard 37: Extramammary Paget's disease of the anus is a rare intraepithelial _____

Answer: adenocarcinoma

Flashcard 38: Pigmentation in acanthosis nigricans is due to _____

Answer: hyperkeratosis

Flashcard 39: What is the mode of inheritence of cylindroma?_____

Answer: Autosomal dominant

Flashcard 40: _____ is the characteristic feature of histopathological feature of Acute eczema

Answer: Spongiosis

Flashcard 41: Melanoma cells have chromatin that is characteristically clumped at the _____ of the nuclear membrane with prominent red (eosinophilic) nucleoli

Answer: periphery

Flashcard 42: _____ is an sweat gland tumor with ductal (apocrine or eccrine) differentiation

Answer: Cylindroma

Flashcard 43: What is the cause of skin pigmentation in hemosiderosis?_____

Answer: Increased melanin

Flashcard 44: Abrasion is an injury that _____ penetrate the full thickness of the epidermis.

Answer: does not (does/does not)

Flashcard 45: Camel foot appearance is seen in histopathology of _____ psoriasis.

Answer: plaque-type Due to degeneration of rete ridges

Flashcard 46: Photoallergic contact dermatitis is a type _____ hypersensitivity reaction

Answer: IV

Flashcard 47: Anucleated "shadow" cells are characteristically seen in _____

Answer: pilomatricoma

Flashcard 48: Touton giant cell is seen in a _____

Answer: xanthoma

Flashcard 49: Tiger tail banding of hair follicle seen under polarizing microscopy is diagnostic of _____

Answer: Trichothiodystrophy

Flashcard 50: _____ nevus is a non-nested dermal infiltration of highly dendritic heavily pigmented nevus cells

Answer: Blue

Flashcard 51: Which layer is involved in blister formation in a superficial partial thickness burn?_____

Answer: Papillary dermis

Flashcard 52: Elongated dermal papillae usually covered with a single layer of epidermal cells is referred to as _____

Answer: Vili

Flashcard 53: Simple lentigo occurs due to an increase in _____ at dermal-epidermal junction.

Answer: melanocytes

Flashcard 54: Bullous pemphigoid presents with a subepidermal blister with an _____ rich infiltrate

Answer: eosinophil

Flashcard 55: Spongiosis mostly involves the stratum _____.

Answer: spinosum

Flashcard 56: _____ stain is used to stain melanin black

Answer: Masson Fontana

Flashcard 57: Most prominent Grenz zone, with expansile and loose granulomas and virchow cells/globi on histology is seen in _____ leprosy

Answer: lepromatous

Flashcard 58: Degeneration of keratinocytes in lichen planus leads to the formation of spaces in the epidermis known as _____

Answer: Max-Joseph Spaces

Flashcard 59: _____ method stains melanin blue-green

Answer: Schmorl s

Flashcard 60: _____ has a characteristic histopathology of "Claw clutching a Ball' appearance

Answer: Lichen nitidus

Flashcard 61: Degenerated necrosed keratinocytes are seen on the Tzank smear in _____

Answer: Toxic epidermal necrolysis

Flashcard 62: What type of nevus shows lymphocytic infiltration surrounding nevus cells?_____

Answer: Halo nevus

Flashcard 63: Slate-brown colour in fixed drug eruption is due to pigmentary incontinence with _____ in the upper dermis and loss of melanin from the epidermis

Answer: melanophages (cells)

Flashcard 64: Ballooning degeneration most commonly involves the stratum _____

Answer: spinosum

Flashcard 65: The pathologic basis of vitiligo is due to loss of _____.

Answer: melanocytes

Flashcard 66: The histopathological section has giant cells with a central ring of nuclei suggestive of _____

Answer: Xanthoma

Flashcard 67: Which appendage tumors show jigsaw puzzle appearance on histology?_____

Answer: Cylindroma

Flashcard 68: Pathophysiology of Miliaria: The _____ are not the primary cause of the obstruction, but arise in the repair process, and further aggravate the obstruction.

Answer: parakeratotic plugs

Flashcard 69: Allergic contact dermatitis is a type of type _____ hypersensitivity reaction

Answer: 4

Flashcard 70: The pathology of alopecia areata is most likely autoimmune and is _____-cell mediated

Answer: T

Flashcard 71: Melanocytic nevi (moles) are common benign neoplasms caused by acquired activating mutations in components of the _____ signaling pathway.

Answer: RAS

Flashcard 72: Dermatitis herpetiformis involves the _____ layer of the dermis

Answer: lamina lucida

Flashcard 73: Neuroendocrine carcinoma of the skin arises from _____ cells

Answer: Merkel

Flashcard 74: What changes are seen in the basal layer in lichenoid reaction?_____

Answer: Liquefaction degeneration and colloid body formation (2)

Flashcard 75: Neurotization of nevus suggests _____ nature of nevus

Answer: benign (benign/malignant)

Flashcard 76: _____ giant cells are lipid-containing macrophages, having a central ring of nuclei while the peripheral cytoplasm is clear due to accumulated lipid

Answer: Touton

Flashcard 77: _____ gland hypertrophy, hyperplasia and fibrosis are characteristic histologic findings in Rhinophyma.

Answer: Sebaceous

Flashcard 78: _____ relates to process of abnormal epidermal cell keratinization.

Answer: Dyskeratosis

Flashcard 79: DNA analysis of person with fine scaly erythematous plaques, showing clonal arrangements of T cell receptor genes, is suggestive of _____

Answer: mycosis fungoides

Flashcard 80: Characteristic peripheral palisading of tumor cells is seen in _____

Answer: BCC::Skin neoplasm