Rheumatology and Immunology — Flashcards

Risk factors for rheumatoid arthritis include HLA-_____, smoking, and silica exposure

Granulomatosis with polyangiitis often presents with upper respiratory tract symptoms, such as _____ or nasopharyngeal ulceration

_____ disease is characterized by speckled ANA and anti-U1 RNP antibodies

Serum sickness presents with fever, urticaria, arthralgia, proteinuria, and lymphadenopathy _____ - 2 weeks after antigen exposure

The characteristics of SLE may be remembered with the mnemonic "RASH OR PAIN":R: _____A: Arthritis (usually involving > 2 joints)S: Serositis (pleuritis and pericarditis)H: Hematologic disorders (e.g. cytopenias)O: Oral or nasopharyngeal ulcers (usually painless)R: Renal diseaseP: PhotosensitivityA: Antinuclear antibodiesI: Immunologic disorder (anti-dsDNA, anti-Sm, antiphospholipid) N: Neurologic disorder (seizures, psychosis)

What antibodies are antiphospholipid antibodies? _____, Lupus anticoagulant, and Anti-beta2 glycoprotein I

_____ syndrome is rheumatoid arthritis with neutropenia and splenomegaly

Most common joint involved in _____ is knee

Hint: gout/pseudo

Granulomatosis with polyangiitis most commonly affects _____ and these patients commonly have a saddle nose deformity

_____-ANCA is triggered by certain infections as proteinase-3 shares similarities with many microbial peptides.