Rheumatology and Immunology — Flashcards

Flashcard 21: The seronegative spondyloarthropathies may be remembered with the mnemonic "PAIR" P: _____A: Ankylosing spondylitisI: Inflammatory bowel diseaseR: Reactive arthritis

Answer: Psoriatic arthritis

Flashcard 22: Rheumatoid arthritis may present with _____ finger deviation and radial wrist deviation

Answer: ulnar

Flashcard 23: _____ syndrome is an autoimmune disease that is associated with exposure to hydrocarbon solvents (e.g. dry-cleaning, paints, dyes) and cigarette smoke

Answer: Goodpasture

Flashcard 24: Limited scleroderma is also referred to as "CREST syndrome": C: _____R: Raynaud phenomenon E: Esophageal dysmotilityS: Sclerodactyly (thick, tight skin)T: Telangiectasias

Answer: Calcinosis cutis (and anti-Centromere Abs)

Flashcard 25: Macrophage activation syndrome presents with a _____ in ESR due to hypofibrinogenemia

Answer: fall

Flashcard 26: _____ is caused by deposition of monosodium urate (MSU) crystals in tissues, especially the joints

Answer: Gout

Flashcard 27: Causes of **lower lobe** lung fibrosis (Mnemonic: **RAIDS**): **R**: _____ **A**: Asbestosis **I**: Idiopathic Pulmonary Fibrosis (IPF) / ILD **D**: Drugs (e.g., Bleomycin, Busulfan, Amiodarone, Methotrexate, Nitrofurantoin) **S**: Scleroderma (Systemic Sclerosis)

Answer: Rheumatoid arthritis

Extra: Mnemonic for **Upper Lobe** Fibrosis: **SCART** - **S**: Silicosis / Sarcoidosis - **C**: Coal worker's pneumoconiosis - **A**: Ankylosing spondylitis - **R**: Radiation - **T**: Tuberculosis / Type 1 Hypersensitivity (EAA)

Flashcard 28: Treatment of Polymyositis / Dermatomyositis involves _____ followed by long-term methotrexate therapy

Answer: corticosteroids

Flashcard 29: Anti-SRP (signal recognition particle) antibodies are associated with _____ (Immune-Mediated Necrotizing Myopathy)

Answer: Necrotizing Myopathy

Extra: Anti-SRP (signal recognition particle) antibodies are highly specific for Immune-Mediated Necrotizing Myopathy (IMNM). This condition is characterized by severe, rapidly progressive proximal muscle weakness, markedly elevated CK, and myofiber necrosis with minimal inflammatory infiltrate on biopsy. It is often associated with a poorer prognosis and potential cardiac involvement compared to other inflammatory myopathies.

Flashcard 30: Mixed connective tissue disease has features of _____, scleroderma, and/or polymyositis

Answer: SLE