Hemoglobin and Iron Metabolism — Flashcards

Primary _____ is due to mutations in the HFE gene on chromosome 6, leading to increased expression of DMT1 and decreased synthesis of Hepcidin

-thalassemia due to a _____ gene deletion is characterized by formation of 4 tetramers, known as Hb Barts

Gower-II has two _____ and two epsilon () chains

Heme is composed of _____ and protoporphyrin

The catabolism of heme from all heme proteins is carried out in the _____ fraction of cells by heme oxygenase.

Disorders of fibrinolysis are due to _____ overactivity, resulting in excessive cleavage of serum fibrinogen

The clotting factor with the shortest half life is Factor _____, whereas the factor with the longest half life is Factor II (thrombin)

Gower-I has two _____ and two epsilon () chains

Each subunit of hemoglobin contains a _____ moiety, which is an iron-binding porphyrin, and a polypeptide chain

Methemoglobin has an _____ affinity for cyanide relative to hemoglobin