Hemoglobin and Iron Metabolism — Flashcards

_____ binds to the ferroportin transporter on intestinal mucosal cells and macrophages, thus inhibiting iron absorption

Porphobilinogen is converted to _____ via the enzyme porphobilinogen deaminase (heme synthesis)

_____ iron (vegetable-derived) must be converted to Fe2+ in the duodenum / proximal jejunum by cytochrome B and/or Vitamin C for absorption

_____ and Fe2+ combine to form heme via the enzyme ferrochelatase

The two embryonic globins are _____ and epsilon ()

In the first step of heme synthesis, _____ and succinyl-CoA are combined to form -aminolevulinic acid via the enzyme -aminolevulinic acid synthase (with vitamin B6 as a cofactor)

_____ iron (meat-derived) is readily absorbed and enters the duodenal cell via the heme transporter

-thalassemia due to a _____ gene deletion is characterized by formation of 4 tetramers, known as Hb Barts

Primary _____ is due to mutations in the HFE gene on chromosome 6, leading to increased expression of DMT1 and decreased synthesis of Hepcidin

The _____ form of hemoglobin has a high affinity for O2