NEET-PG 2013 - Ophthalmology Practice Questions

Q: What is the condition characterized by a relative afferent pupillary defect?

Marcus Gunn pupil. ***Marcus Gunn pupil, a defect in the afferent pathway of the eye*** - A **Marcus Gunn pupil**, also known as a **relative afferent pupillary defect (RAPD)**, occurs due to a lesion or dysfunction in the **afferent (sensory) pathway** of one eye. - This results in an asymmetric response to light, where the pupil of the affected eye appears to dilate paradoxically when light is swung from the unaffected to the affected eye during the **swinging flashlight test**. *Efferent pathway defect* - An **efferent pathway defect** (e.g., in the oculomotor nerve, CN III) would cause a **fixed, dilated pupil** with impaired direct and consensual light reflexes, rather than an RAPD. - Such a defect would typically affect the motor response of the pupil, causing it to be unable to constrict. *Cerebral lesion* - While certain cerebral lesions can affect pupillary responses, a **relative afferent pupillary defect** specifically points to an issue in the direct sensory input from the retina to the brainstem. - Large **cerebral lesions** are more likely to cause other neurological signs or abnormalities in the motor control of the eye. *Total afferent pupillary defect* - A **total afferent pupillary defect**, often seen in **amaurotic pupil** (blind eye without light perception), would result in no direct or consensual light response in the affected eye. - In a RAPD, there is still some, albeit reduced, response to light, making it a **relative** defect rather than a total absence of afferent signaling.

Q: Arcuate field defect akin to glaucoma is seen in?

Optic nerve lesion. ***Optic nerve lesion*** - An **arcuate field defect** is a specific pattern of visual field loss that follows the course of nerve fibers in the retina and is characteristic of **optic nerve damage**, similar to what is seen in glaucoma. - This type of defect is due to damage to the **bundle of retinal nerve fibers** that arch above or below the macula, often causing a scotoma (blind spot) that respects the horizontal meridian. - Common causes include **anterior ischemic optic neuropathy (AION)**, **optic neuritis**, and other optic nerve pathologies that affect the nerve fiber layer. *Pituitary adenoma* - A pituitary adenoma typically causes a **bitemporal hemianopsia** due to compression of the optic chiasm. - This visual field defect involves the lateral halves of both visual fields, which is different from an arcuate defect. *Posterior cerebral artery infarct* - An infarct in the posterior cerebral artery typically leads to a **homonymous hemianopsia** (loss of half of the visual field on the same side in both eyes) or a quadrantanopsia. - This type of defect results from damage to the **visual cortex** or optic radiations, not the optic nerve itself in a glaucoma-like pattern. *None of the options* - This is incorrect because **optic nerve lesion** is a valid and correct answer. - Optic nerve pathologies are well-established causes of arcuate field defects similar to those seen in glaucoma.

Q: Foster Kennedy syndrome is

I/L Optic atrophy C/L papilloedema. ***I/L Optic atrophy C/L papilloedema*** - **Foster Kennedy syndrome** is characterized by the combination of **ipsilateral optic atrophy** and **contralateral papilledema**. - This constellation of signs is typically caused by a **frontal lobe mass** (e.g., meningioma or glioma) that directly compresses the ipsilateral optic nerve, leading to atrophy, while also causing increased **intracranial pressure** that manifests as papilledema in the contralateral eye. *I/L Papilloedema with C/L optic atrophy* - This describes the reverse of Foster Kennedy syndrome and is not a recognized clinical entity associated with a specific pathological process. - Papilledema is due to **increased intracranial pressure**, and optic atrophy is due to nerve damage; these would typically manifest in specific patterns related to the location and timing of the insult. *I/L Optic atrophy with papilloedema* - This option describes both conditions occurring in the **same (ipsilateral) eye**, which contradicts the characteristic presentation of Foster Kennedy syndrome. - While an eye can have both optic atrophy and papilledema (e.g., resolving papilledema or an underlying condition), it is not the defining feature of Foster Kennedy syndrome. *UL Papilloedema C/L papilitis* - This option mentions **papilledema** in one eye (unilateral or ipsilateral is implied) and **papillitis** in the other. - **Papillitis** is an inflammatory condition of the optic nerve head, while papilledema is due to increased intracranial pressure. This combination is not characteristic of Foster Kennedy syndrome, which specifically involves atrophy and papilledema due to a mass lesion.

Q: From which surface is the Purkinje IV image formed?

Posterior surface of lens. ***Posterior surface of lens*** - The **Purkinje IV image** is formed by reflection from the **posterior surface of the lens**, which is the most curved surface in the eye. - Due to the higher curvature and refractive index difference, this surface acts as a concave mirror, producing an **inverted, virtual image**. *Anterior surface of cornea* - The **Purkinje I image** is formed from the **anterior surface of the cornea**, which is the primary reflective surface of the eye. - This image is **bright, erect, and virtual**, serving as a basic reference for eye position. *Posterior surface of cornea* - The **Purkinje II image** originates from the **posterior surface of the cornea**, a much less curved and reflective surface than the anterior. - This image is typically **fainter** and less frequently used in clinical assessments due to its reduced visibility. *Anterior surface of lens* - The **Purkinje III image** is generated by reflection from the **anterior surface of the lens**. - This image is **inverted and virtual**, and its movement relative to Purkinje I can indicate lens accommodation changes.

Q: Choroidal neovascularization is most commonly seen in which of the following refractive errors?

Myopia. ***Myopia*** - High myopia, particularly **pathologic myopia** (>6D or axial length >26mm), is a significant risk factor for **choroidal neovascularization (CNV)** among refractive errors due to the elongation of the eyeball stretching and thinning the choroid and Bruch's membrane. - The mechanical stress and associated **degenerative changes** in the posterior segment can lead to ruptures in Bruch's membrane, facilitating the growth of new, fragile blood vessels from the choroid into the subretinal space. - **Pathologic myopia** is the **second most common cause of CNV overall** (after age-related macular degeneration) and the **most common cause in patients under 50 years**. *Hypermetropia* - Hypermetropia (farsightedness) is associated with a **shorter axial length** of the eye, which generally reduces the risk of the structural changes that predispose to CNV. - While other conditions can cause CNV, hypermetropia itself is **not a risk factor** for its development. *Presbyopia* - Presbyopia is an **age-related loss of accommodation** due to hardening of the lens and weakening of the ciliary muscle, affecting near vision. - It is a refractive change related to the lens's flexibility and **not directly to the structural changes** in the choroid or retina that lead to CNV. *Astigmatism* - Astigmatism is a refractive error where the eye's cornea or lens has **irregular curvature**, causing blurred vision at all distances. - It is a **surface curvature issue** and does not typically involve the deep structural changes in the choroid or retina that are conducive to choroidal neovascularization.

Q: During retinoscopy of a 30-year-old male, which cycloplegic is used routinely?

Cyclopentolate 1% drop. ***Cyclopentolate 1% drop*** - When cycloplegia is required for retinoscopy, **cyclopentolate 1%** is the preferred agent in adults due to its **rapid onset** (30-60 minutes) and **intermediate duration** (6-24 hours). - It provides adequate **cycloplegia** (paralysis of accommodation) to reveal the full refractive error without the prolonged effects of atropine. - **Clinical note:** In routine practice, most adults aged 30 years undergo retinoscopy **without cycloplegia** as accommodation is usually not a significant factor. Cycloplegia in adults is reserved for specific indications like suspected latent hyperopia, accommodative spasm, or unreliable subjective refraction. *Homatropine 2% drop* - Homatropine has a **slower onset** (1 hour) and **longer duration** (1-3 days) compared to cyclopentolate, making it less practical for routine diagnostic use. - It is typically used for therapeutic purposes such as in **anterior uveitis** to provide cycloplegia and mydriasis. *Atropine 1% ointment* - Atropine is the **strongest** and **longest-acting** cycloplegic with effects lasting **7-14 days**, which is excessively long for diagnostic retinoscopy. - It is primarily used in **young children** (especially under 5 years) for accurate refraction and in therapeutic settings for **cycloplegic refraction in amblyopia** treatment. *None of the options* - While it's true that **routine retinoscopy in a healthy 30-year-old adult** typically does NOT require cycloplegia, this question asks which cycloplegic would be used **when indicated**. - Among the available cycloplegic options, **cyclopentolate** remains the appropriate choice for adults when cycloplegia is deemed necessary.

Q: Foldable lens is made up of?

Silicone. ***Silicone*** - **Silicone** was one of the **first materials** used for foldable intraocular lenses (IOLs) and remains widely used today. - Its excellent **elastomeric properties** allow the lens to be folded or rolled for insertion through a **small incision** (typically 2.8-3.2 mm) in modern cataract surgery. - Silicone IOLs are **hydrophobic** and have high biocompatibility with minimal inflammatory response. - **Clinical advantage**: Silicone's flexibility enables **sutureless small-incision cataract surgery**, reducing astigmatism and recovery time. *PMMA* - **PMMA (Polymethyl methacrylate)** is a **rigid material** and was the standard for IOLs before the development of foldable lenses. - Its rigidity requires a **large incision** (5.5-7 mm) for insertion, resulting in more induced astigmatism and longer recovery. - PMMA is not foldable and therefore is not used in modern small-incision cataract surgery. *Hydrogel* - **Hydrophilic acrylic (hydrogel)** is actually another material used for foldable IOLs, along with hydrophobic acrylic. - However, in the context of this question, **silicone** is the most recognized answer as it was the **first foldable material** introduced. - Hydrogel IOLs can absorb water and require different handling during insertion. *None of the options* - This is incorrect as **silicone** is definitively a material used for foldable IOLs.

Q: In senile nuclear cataract what type of myopia is seen?

Index myopia. **Index myopia** - **Senile nuclear cataract** involves opacification and hardening of the lens nucleus, which increases the **refractive index** of the lens. - This results in a stronger refractive power of the eye, causing light to focus in front of the retina, characteristic of **myopia**. *Curvature myopia* - Occurs when there is an increase in the **curvature of the cornea** or lens, leading to increased refractive power. - While lens curvature can change, the primary mechanism in nuclear cataracts is refractive index change, not solely curvature. *Axial myopia* - Arises from an **elongation of the eyeball**, making the axial length too long relative to the refractive power. - This is a structural change in the eye's shape, not directly caused by changes within the lens itself due to cataract. *Lenticular myopia* - This term is a broader category that refers to myopia caused by changes in the lens, which **index myopia** falls under. - However, "index myopia" is more specific and accurately describes the underlying mechanism in senile nuclear cataracts.

Q: Which of the following conditions is associated with ectopia lentis?

Homocystinuria. ***Homocystinuria*** - **Ectopia lentis** (lens dislocation) is a common and characteristic ocular manifestation of homocystinuria. - The lens typically dislocates **downward and inward**, differentiating it from Marfan syndrome. *Alport syndrome* - Characterized by **glomerulonephritis**, **sensorineural hearing loss**, and ocular abnormalities. - Ocular manifestations include **anterior lenticonus** (which can be mistaken for ectopia lentis in some descriptions), posterior polymorphous corneal dystrophy, and retinal flecks, but not classic ectopia lentis. *Lowe syndrome* - Also known as oculocerebrorenal syndrome of Lowe, it primarily affects the **eyes, brain, and kidneys**. - Ocular features include **congenital cataracts** and glaucoma, but not ectopia lentis. *Sulphite oxidase deficiency* - This is a rare metabolic disorder affecting the metabolism of sulfur-containing amino acids, leading to severe neurological symptoms. - While it can manifest with **cataracts** and **lens subluxation** in some cases, ectopia lentis is more characteristically associated with homocystinuria, and the overall clinical picture of sulphite oxidase deficiency is dominated by severe neurological impairment.

Q: Polyopia/diplopia is seen in which type of cataract?

Cortical cataract. ***Cortical cataract*** - **Cortical cataracts** cause spokes or vacuoles that refract light in multiple directions, leading to **polyopia** or **diplopia**. - The irregular opacities disrupt the light path, causing the brain to perceive **multiple images**. *Nuclear cataract* - **Nuclear cataracts** primarily affect central vision and cause **myopic shift**, not typically polyopia or diplopia. - They cause **blurry vision** and difficulty seeing in dim light as the lens nucleus hardens and yellows. *Posterior subcapsular cataract* - **Posterior subcapsular cataracts** are characterized by glare and difficulty with reading, mainly affecting near vision. - They form at the back of the lens, close to the nodal point, causing earlier onset of **visual symptoms** with less impact on polyopia. *Anterior polar cataract* - **Anterior polar cataracts** are usually small, well-demarcated opacities at the front of the lens that typically do not cause significant visual impairment. - They rarely cause **polyopia** unless they are very large or dense, which is uncommon.

Question 1

What is the condition characterized by a relative afferent pupillary defect?

Accepted Answer

Marcus Gunn pupil

Answer

Efferent pathway defect

Answer

Cerebral lesion

Answer

Total afferent pupillary defect

Question 2

Arcuate field defect akin to glaucoma is seen in?

Accepted Answer

Optic nerve lesion

Answer

Pituitary adenoma

Answer

Posterior cerebral artery infarct

Answer

None of the options

Question 3

Foster Kennedy syndrome is

Accepted Answer

I/L Optic atrophy C/L papilloedema

Answer

I/L Optic atrophy with papilloedema

Answer

I/L Papilloedema with C/L optic atrophy

Answer

I/L Papilloedema C/L papilitis

Question 4

From which surface is the Purkinje IV image formed?

Accepted Answer

Posterior surface of lens

Answer

Anterior surface of cornea

Answer

Posterior surface of cornea

Answer

Anterior surface of lens

Question 5

Choroidal neovascularization is most commonly seen in which of the following refractive errors?

Accepted Answer

Myopia

Answer

Hypermetropia

Answer

Presbyopia

Answer

Astigmatism

Question 6

During retinoscopy of a 30-year-old male, which cycloplegic is used routinely?

Accepted Answer

Cyclopentolate 1% drop

Answer

Homatropine 2% drop

Answer

Atropine 1% ointment

Answer

None of the options

Question 7

Foldable lens is made up of?

Accepted Answer

Silicone

Answer

PMMA

Answer

Hydrogel

Answer

None of the options

Question 8

In senile nuclear cataract what type of myopia is seen?

Accepted Answer

Index myopia

Answer

Curvature myopia

Answer

Axial myopia

Answer

Lenticular myopia

Question 9

Which of the following conditions is associated with ectopia lentis?

Accepted Answer

Homocystinuria

Answer

Alport syndrome

Answer

Lowe syndrome

Answer

Sulphite oxidase deficiency

Question 10

Polyopia/diplopia is seen in which type of cataract?

Accepted Answer

Cortical cataract

Answer

Nuclear cataract

Answer

Posterior subcapsular cataract

Answer

Anterior polar cataract

NEET-PG 2013 — Ophthalmology