INI-CET 2018 - Dermatology PYQs Practice Questions

Q: A 28-year-old lady has asymptomatic dome-shaped small lesions on the forehead for the past 2 months. She lives with her 2-year-old daughter who also is having similar lesions. What is the causative agent of these lesions?

Poxvirus. ***Poxvirus*** - The description of asymptomatic, **dome-shaped small lesions** and their presence in both a mother and her young child strongly suggests **molluscum contagiosum**, which is caused by a **poxvirus**. - Molluscum contagiosum lesions are typically **umbilicated**, which often appears dome-shaped, and are highly contagious, commonly spread through close contact. *HSV* - **Herpes Simplex Virus (HSV)** typically causes clusters of **painful vesicles** on an erythematous base, which later crust over. - The lesions described are asymptomatic and dome-shaped, not vesicular or painful. *HPV* - **Human Papillomavirus (HPV)** causes **warts**, which are rough, verrucous papules or plaques, not smooth dome-shaped lesions. - While warts can spread through close contact, their morphology differs significantly from the lesions described. *VZV* - **Varicella-Zoster Virus (VZV)** causes **chickenpox** (widespread itchy vesicles) or **shingles** (painful dermatomal rash). - The lesions described do not fit the characteristic presentation of either chickenpox or shingles, as they are asymptomatic and dome-shaped. [Practice more Dermatology PYQs on OnCourse]

Q: A patient presents with 1-year history of painful nodulocystic acne as shown in the image. Which of the following is the drug of choice for this case?

Oral isotretinoin. ***Oral isotretinoin*** - This patient presents with severe **nodulocystic acne**, which is characterized by deep, painful lesions that often lead to scarring, and has been present for 1 year. Oral isotretinoin is the **drug of choice** for severe, recalcitrant nodulocystic acne due to its ability to target all four pathogenic factors of acne. - Isotretinoin reduces **sebum production**, normalizes follicular keratinization, decreases *P. acnes* colonization, and has anti-inflammatory effects, making it highly effective for severe cases. *Topical clindamycin* - **Topical clindamycin** is an antibiotic primarily used for mild to moderate inflammatory acne, particularly papules and pustules. - It is **insufficient** for severe nodulocystic acne due to its limited penetration and inability to address the deeper, more severe inflammation and scarring potential. *Topical adapalene* - **Topical adapalene** is a retinoid used for mild to moderate comedonal and inflammatory acne. It helps normalize follicular keratinization and has anti-inflammatory properties. - While effective for less severe acne, it is generally **not potent enough** to treat severe nodulocystic acne effectively, especially given its chronic nature as described. *Oral doxycycline* - **Oral doxycycline** is a systemic antibiotic used for moderate to severe inflammatory acne, primarily due to its anti-inflammatory properties and its effect on reducing *P. acnes*. - Although it can be used for severe acne, it is **less effective** than oral isotretinoin for nodulocystic acne, especially in the long-term, and does not address the underlying pathogenesis (like sebaceous gland activity) as comprehensively as isotretinoin. [Practice more Dermatology PYQs on OnCourse]

Q: What is the best management of the case shown?

Stop smoking and screen for cancer. ***Stop smoking and screen for cancer*** - The image shows **smoker's palate (nicotinic stomatitis)**, characterized by diffuse white thickening of the palatal mucosa with red dots representing inflamed salivary gland orifices. This condition is caused by **chronic heat exposure from smoking**. - While generally benign, smoker's palate indicates a high risk for other **oral cancers**, particularly those involving the lips, tongue, and floor of the mouth, necessitating smoking cessation and regular screening. *Dapsone plus steroids* - This combination is typically used for **autoimmune blistering diseases** like **dermatitis herpetiformis** or **pemphigoid**, which present with different clinical features. - Smoker's palate is not an autoimmune condition and would not respond to these treatments. *Vitamin supplements* - Vitamin supplements are not a treatment for smoker's palate, as it is a localized lesion caused by irritation from smoke. - While general nutritional support is good, it doesn't address the underlying cause or potential complications of this specific condition. *Antifungals for oral candidiasis* - **Oral candidiasis (thrush)** typically presents as removable white plaques on the oral mucosa, often associated with immunosuppression or antibiotic use. - The lesions in the image are firmly attached, non-removable, and show specific morphological changes (red dots), which are not characteristic of candidiasis. [Practice more Dermatology PYQs on OnCourse]

Q: A patient presented with fever and joint pain for which she was put on NSAIDs. After 10 days she developed a skin lesion as shown in the image. Diagnosis is:

Fixed drug eruption. ***Fixed drug eruption*** - The appearance of a **well-demarcated, erythematous, and pigmented patch** on the skin, combined with a history of recent **NSAID use** and prior fever/arthralgia (suggesting possible prior exposure and sensitization to the drug), is highly characteristic of fixed drug eruption. - FDEs typically recur at the **same site(s)** upon re-exposure to the offending drug, and NSAIDs are known culprits. The lesion often heals with post-inflammatory **hyperpigmentation**. *Chikungunya* - While Chikungunya causes **fever and severe joint pain**, the rash associated with it is typically a more generalized, **maculopapular rash**, not a localized, well-demarcated lesion as seen in the image. - The onset of the skin lesion **10 days after starting NSAIDs** points more towards a drug reaction than a viral exanthem, especially with the appearance of a **pigmented patch**. *Dengue* - Dengue fever presents with **fever, joint pain, and often a rash**, but the rash is usually a generalized **macular or maculopapular eruption**, sometimes with petechiae, and is not typically a single, demarcated, post-inflammatory hyperpigmented lesion. - Similar to Chikungunya, the timing and morphology of the lesion are not typical for Dengue rash. *Melasma* - Melasma is a chronic skin condition causing **dark, discolored patches** on the face, primarily due to hormonal changes (e.g., pregnancy, birth control) or sun exposure. - It does not typically present acutely after drug ingestion with accompanying inflammation or an eruption-like morphology. [Practice more Dermatology PYQs on OnCourse]

Question 1

A 28-year-old lady has asymptomatic dome-shaped small lesions on the forehead for the past 2 months. She lives with her 2-year-old daughter who also is having similar lesions. What is the causative agent of these lesions?

Accepted Answer

Poxvirus

Answer

HSV

Answer

HPV

Answer

VZV

Question 2

A patient presents with 1-year history of painful nodulocystic acne as shown in the image. Which of the following is the drug of choice for this case?

Accepted Answer

Oral isotretinoin

Answer

Topical clindamycin

Answer

Topical adapalene

Answer

Oral doxycycline

Question 3

What is the best management of the case shown?

Accepted Answer

Stop smoking and screen for cancer

Answer

Dapsone plus steroids

Answer

Vitamin supplements

Answer

Antifungals for oral candidiasis

Question 4

A patient presented with fever and joint pain for which she was put on NSAIDs. After 10 days she developed a skin lesion as shown in the image. Diagnosis is:

Accepted Answer

Fixed drug eruption

Answer

Chikungunya

Answer

Dengue

Answer

Melasma

INI-CET 2018 — Dermatology